Development of Novel Physical Methods to Enhance Contrast and Sensitivity in Magnetic Resonance Imaging

dc.contributor.advisor

Warren, Warren S

dc.contributor.author

Jenista, Elizabeth

dc.date.accessioned

2011-01-05T14:41:37Z

dc.date.available

2011-01-05T14:41:37Z

dc.date.issued

2010

dc.department

Chemistry

dc.description.abstract

The purpose of this thesis is to report technological developments in contrast mechanisms for MRI. The search for new forms of contrast is on-going, with the hope that new contrast mechanisms and new contrast agents will provide unique insights into various molecular processes and disease states. In this thesis, we will describe new contrast mechanisms developed by manipulating the inherent physics of the system, as well as the development of exogenous contrast agents. More specifically, we will describe the application of iMQCs (intermolecular multiple quantum coherences) to thermometry and structural imaging, and the unique information provided from these studies. We will also describe methods for migrating iMQC-based pulse sequences from a Bruker research console onto a clinical GE console, thus enabling the application of iMQCs to humans. We will describe the development of hyperpolarized contrast agents which have the potential to provide an unprecedented level of molecular contrast to MRI and the development of techniques to enhance the lifetime of these hyperpolarized contrast agents. Finally, we will discuss a new type of T2 -weighted imaging which significantly improves the refocusing of CPMG-type sequences.

dc.identifier.uri

https://hdl.handle.net/10161/3031

dc.subject

Chemistry, Physical

dc.subject

contrast

dc.subject

hyperpolarization

dc.subject

magnetic resoance imaging

dc.subject

physics

dc.subject

thermometry

dc.title

Development of Novel Physical Methods to Enhance Contrast and Sensitivity in Magnetic Resonance Imaging

dc.type

Dissertation

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
D_Jenista_Elizabeth_a_2010.pdf
Size:
8.43 MB
Format:
Adobe Portable Document Format

Collections