Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion.

dc.contributor.author

Dunn, Timothy W

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Mu, Yu

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Narayan, Sujatha

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Randlett, Owen

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Naumann, Eva A

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Naumann, Eva A

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Yang, Chao-Tsung

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Schier, Alexander F

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Schier, Alexander F

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Freeman, Jeremy

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Engert, Florian

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Ahrens, Misha B

dc.date.accessioned

2018-07-30T18:47:28Z

dc.date.available

2018-07-30T18:47:28Z

dc.date.issued

2016-03-22

dc.date.updated

2018-07-30T18:47:14Z

dc.description.abstract

In the absence of salient sensory cues to guide behavior, animals must still execute sequences of motor actions in order to forage and explore. How such successive motor actions are coordinated to form global locomotion trajectories is unknown. We mapped the structure of larval zebrafish swim trajectories in homogeneous environments and found that trajectories were characterized by alternating sequences of repeated turns to the left and to the right. Using whole-brain light-sheet imaging, we identified activity relating to the behavior in specific neural populations that we termed the anterior rhombencephalic turning region (ARTR). ARTR perturbations biased swim direction and reduced the dependence of turn direction on turn history, indicating that the ARTR is part of a network generating the temporal correlations in turn direction. We also find suggestive evidence for ARTR mutual inhibition and ARTR projections to premotor neurons. Finally, simulations suggest the observed turn sequences may underlie efficient exploration of local environments.

dc.identifier.issn

2050-084X

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2050-084X

dc.identifier.uri

https://hdl.handle.net/10161/17284

dc.language

eng

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eLife Sciences Publications, Ltd

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eLife

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10.7554/elife.12741

dc.subject

Rhombencephalon

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Animals

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Zebrafish

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Brain Mapping

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Behavior, Animal

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Locomotion

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Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion.

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Journal article

pubs.begin-page

e12741

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MARCH2016

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School of Medicine

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Duke

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Neurobiology

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Basic Science Departments

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Duke Institute for Brain Sciences

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Staff

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Statistical Science

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Trinity College of Arts & Sciences

pubs.publication-status

Published

pubs.volume

5

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