Regulatory T Cells Keep Pancreatic Cancer at Bay

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2020-03-01

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Abstract

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Summary:</jats:title> <jats:p>Although CD4+ FOXP3+ T regulatory (Treg) cells are well-known mediators of immunologic tolerance, their influences in the tumor microenviroment are incompletely understood. Writing in this issue of Cancer Discovery, Zhang and colleagues demonstrate that in pancreatic cancer, Treg cells promote the differentiation of tumor-restraining myofibroblastic cancer-associated fibroblasts, challenging the existing notion that Treg cells enable tumor progression.</jats:p> <jats:p>See related article by Zhang et al., p. 422.</jats:p> </jats:sec>

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10.1158/2159-8290.cd-20-0002

Publication Info

Aykut, Berk, Ruonan Chen and George Miller (2020). Regulatory T Cells Keep Pancreatic Cancer at Bay. Cancer Discovery, 10(3). pp. 345–347. 10.1158/2159-8290.cd-20-0002 Retrieved from https://hdl.handle.net/10161/30171.

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Aykut

Berk Aykut

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College/University: Ruprecht Karl University of Heidelberg

Medical School: Ruprecht Karl University of Heidelberg


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