Regulatory T Cells Keep Pancreatic Cancer at Bay
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2020-03-01
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<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Summary:</jats:title> <jats:p>Although CD4+ FOXP3+ T regulatory (Treg) cells are well-known mediators of immunologic tolerance, their influences in the tumor microenviroment are incompletely understood. Writing in this issue of Cancer Discovery, Zhang and colleagues demonstrate that in pancreatic cancer, Treg cells promote the differentiation of tumor-restraining myofibroblastic cancer-associated fibroblasts, challenging the existing notion that Treg cells enable tumor progression.</jats:p> <jats:p>See related article by Zhang et al., p. 422.</jats:p> </jats:sec>
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Aykut, Berk, Ruonan Chen and George Miller (2020). Regulatory T Cells Keep Pancreatic Cancer at Bay. Cancer Discovery, 10(3). pp. 345–347. 10.1158/2159-8290.cd-20-0002 Retrieved from https://hdl.handle.net/10161/30171.
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Berk Aykut
College/University: Ruprecht Karl University of Heidelberg
Medical School: Ruprecht Karl University of Heidelberg
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