An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention.

dc.contributor.author

Zaer, Hamed

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Deshmukh, Ashlesha

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Orlowski, Dariusz

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Fan, Wei

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Prouvot, Pierre-Hugues

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Glud, Andreas Nørgaard

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Jensen, Morten Bjørn

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Worm, Esben Schjødt

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Lukacova, Slávka

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Mikkelsen, Trine Werenberg

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Fitting, Lise Moberg

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Adler, John R

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Schneider, M Bret

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Jensen, Martin Snejbjerg

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Fu, Quanhai

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Go, Vinson

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Morizio, James

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Sørensen, Jens Christian Hedemann

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Stroh, Albrecht

dc.date.accessioned

2023-08-09T17:45:37Z

dc.date.available

2023-08-09T17:45:37Z

dc.date.issued

2021-01

dc.date.updated

2023-08-09T17:45:33Z

dc.description.abstract

Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.

dc.identifier.issn

1662-5161

dc.identifier.issn

1662-5161

dc.identifier.uri

https://hdl.handle.net/10161/28710

dc.language

eng

dc.publisher

Frontiers Media SA

dc.relation.ispartof

Frontiers in human neuroscience

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10.3389/fnhum.2021.618626

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EEG

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Göttingen minipig

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animal model

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brain-machine (computer) interface

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closed-loop

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electrophysiology

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neuromodulation

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stereotactic radiosurgery

dc.title

An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention.

dc.type

Journal article

duke.contributor.orcid

Morizio, James|0000-0002-1463-9257

pubs.begin-page

618626

pubs.organisational-group

Duke

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Pratt School of Engineering

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Electrical and Computer Engineering

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Institutes and Provost's Academic Units

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University Institutes and Centers

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Initiatives

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Nicholas Institute for Energy, Environment & Sustainability

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Nicholas Institute for Energy, Environment & Sustainability

pubs.publication-status

Published

pubs.volume

15

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