White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football.

dc.contributor.author

Kuzminski, SJ

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Clark, MD

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Fraser, MA

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Haswell, CC

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Morey, RA

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Liu, C

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Choudhury, KR

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Guskiewicz, KM

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Petrella, JR

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United States

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2018-01-02T14:29:55Z

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2018-01-02T14:29:55Z

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2017-12-21

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BACKGROUND AND PURPOSE: The effect of exposing the developing brain of a high school football player to subconcussive impacts during a single season is unknown. The purpose of this pilot study was to use diffusion tensor imaging to assess white matter changes during a single high school football season, and to correlate these changes with impacts measured by helmet accelerometer data and neurocognitive test scores collected during the same period. MATERIALS AND METHODS: Seventeen male athletes (mean age, 16 ± 0.73 years) underwent MR imaging before and after the season. Changes in fractional anisotropy across the white matter skeleton were assessed with Tract-Based Spatial Statistics and ROI analysis. RESULTS: The mean number of impacts over a 10-g threshold sustained was 414 ± 291. Voxelwise analysis failed to show significant changes in fractional anisotropy across the season or a correlation with impact frequency, after correcting for multiple comparisons. ROI analysis showed significant (P < .05, corrected) decreases in fractional anisotropy in the fornix-stria terminalis and cingulum hippocampus, which were related to impact frequency. The effects were strongest in the fornix-stria terminalis, where decreases in fractional anisotropy correlated with worsening visual memory. CONCLUSIONS: Our findings suggest that subclinical neurotrauma related to participation in American football may result in white matter injury and that alterations in white matter tracts within the limbic system may be detectable after only 1 season of play at the high school level.

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https://www.ncbi.nlm.nih.gov/pubmed/29269405

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ajnr.A5489

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1936-959X

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https://hdl.handle.net/10161/15942

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eng

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American Society of Neuroradiology (ASNR)

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AJNR Am J Neuroradiol

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10.3174/ajnr.A5489

dc.title

White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football.

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Journal article

duke.contributor.orcid

Petrella, JR|0000-0003-2596-217X

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/29269405

pubs.organisational-group

Clinical Science Departments

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Duke

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Duke Institute for Brain Sciences

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Duke-UNC Center for Brain Imaging and Analysis

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Institutes and Centers

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Institutes and Provost's Academic Units

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Psychiatry & Behavioral Sciences

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Psychiatry & Behavioral Sciences, Translational Neuroscience

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School of Medicine

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Temp group - logins allowed

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University Institutes and Centers

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Published online

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