Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study.
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2019-04-15
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Abstract
Background
Oxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA), with all-cause mortality in older adults.Methods
This is a community-based cohort study of 2224 participants (women:1227, median age: 86 years). We included individuals aged 65 or above and with plasma SOD activity and/or MDA tests at baseline. We evaluated the hazard ratios (HRs) and 95% confidence intervals (CIs) by multivariable Cox models.Results
We documented 858 deaths during six years of follow-up. There was a significant interaction effect of sex with the association between SOD activity and mortality (P < 0.001). Compared with the lowest quintile, the risk of all-cause mortality was inversely associated with increasing quintiles of plasma SOD activity in women(P-trend< 0.001), with adjusted HRs for the second through fifth quintiles of 0.73 (95% CI 0.53-1.02), 0.52(95% CI 0.38-0.72), 0.53(95% CI 0.39-0.73), and 0.48(95% CI 0.35-0.66). There were no significant associations between SOD activity and mortality in men (P-trend = 0.64), and between MDA and mortality in all participants (P-trend = 0.79).Conclusions
Increased activity of SOD was independently associated with lower all-cause mortality in older women but not in men. This epidemiological study lent support for the free radical/oxidative stress theory of aging.Type
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Mao, Chen, Jin-Qiu Yuan, Yue-Bin Lv, Xiang Gao, Zhao-Xue Yin, Virginia Byers Kraus, Jie-Si Luo, Choy-Lye Chei, et al. (2019). Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study. BMC geriatrics, 19(1). p. 104. 10.1186/s12877-019-1109-z Retrieved from https://hdl.handle.net/10161/22786.
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Scholars@Duke
Yi Zeng
(1) Socioeconomic, behavior, environmental and genetic determinants of healthy aging and healthy longevity;
(2) Factors related to elderly disability and mental health;
(3) Methods of family households and elderly living arrangements forecasting/analysis and their applications in health services and socioeconomic planning, and market studies;
(4) Policy analysis in population aging, social welfare, retirement, and fertility transitions.
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