Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study.
| dc.contributor.author | Mao, Chen | |
| dc.contributor.author | Yuan, Jin-Qiu | |
| dc.contributor.author | Lv, Yue-Bin | |
| dc.contributor.author | Gao, Xiang | |
| dc.contributor.author | Yin, Zhao-Xue | |
| dc.contributor.author | Kraus, Virginia Byers | |
| dc.contributor.author | Luo, Jie-Si | |
| dc.contributor.author | Chei, Choy-Lye | |
| dc.contributor.author | Matchar, David Bruce | |
| dc.contributor.author | Zeng, Yi | |
| dc.contributor.author | Shi, Xiao-Ming | |
| dc.date.accessioned | 2021-05-05T06:36:39Z | |
| dc.date.available | 2021-05-05T06:36:39Z | |
| dc.date.issued | 2019-04-15 | |
| dc.date.updated | 2021-05-05T06:36:38Z | |
| dc.description.abstract | BackgroundOxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA), with all-cause mortality in older adults.MethodsThis is a community-based cohort study of 2224 participants (women:1227, median age: 86 years). We included individuals aged 65 or above and with plasma SOD activity and/or MDA tests at baseline. We evaluated the hazard ratios (HRs) and 95% confidence intervals (CIs) by multivariable Cox models.ResultsWe documented 858 deaths during six years of follow-up. There was a significant interaction effect of sex with the association between SOD activity and mortality (P < 0.001). Compared with the lowest quintile, the risk of all-cause mortality was inversely associated with increasing quintiles of plasma SOD activity in women(P-trend< 0.001), with adjusted HRs for the second through fifth quintiles of 0.73 (95% CI 0.53-1.02), 0.52(95% CI 0.38-0.72), 0.53(95% CI 0.39-0.73), and 0.48(95% CI 0.35-0.66). There were no significant associations between SOD activity and mortality in men (P-trend = 0.64), and between MDA and mortality in all participants (P-trend = 0.79).ConclusionsIncreased activity of SOD was independently associated with lower all-cause mortality in older women but not in men. This epidemiological study lent support for the free radical/oxidative stress theory of aging. | |
| dc.identifier | 10.1186/s12877-019-1109-z | |
| dc.identifier.issn | 1471-2318 | |
| dc.identifier.issn | 1471-2318 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Springer Science and Business Media LLC | |
| dc.relation.ispartof | BMC geriatrics | |
| dc.relation.isversionof | 10.1186/s12877-019-1109-z | |
| dc.subject | Humans | |
| dc.subject | Malondialdehyde | |
| dc.subject | Superoxide Dismutase | |
| dc.subject | Mortality | |
| dc.subject | Cohort Studies | |
| dc.subject | Follow-Up Studies | |
| dc.subject | Prospective Studies | |
| dc.subject | Age Factors | |
| dc.subject | Sex Factors | |
| dc.subject | Oxidative Stress | |
| dc.subject | Aged | |
| dc.subject | Aged, 80 and over | |
| dc.subject | Female | |
| dc.subject | Male | |
| dc.subject | Independent Living | |
| dc.subject | Biomarkers | |
| dc.title | Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Kraus, Virginia Byers|0000-0001-8173-8258 | |
| duke.contributor.orcid | Matchar, David Bruce|0000-0003-3020-2108 | |
| pubs.begin-page | 104 | |
| pubs.issue | 1 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke Molecular Physiology Institute | |
| pubs.organisational-group | Orthopaedics | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Medicine, Rheumatology and Immunology | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Duke Global Health Institute | |
| pubs.organisational-group | Medicine, General Internal Medicine | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Duke Population Research Institute | |
| pubs.organisational-group | Center for Population Health & Aging | |
| pubs.organisational-group | Duke Population Research Center | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Medicine, Geriatrics | |
| pubs.organisational-group | Sanford School of Public Policy | |
| pubs.publication-status | Published | |
| pubs.volume | 19 |
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