Engineering Exquisite Nanoscale Behavior with DNA

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Date

2012

Authors

Gopalkrishnan, Nikhil

Advisors

Reif, John H

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Abstract

Self-assembly is a pervasive natural phenomenon that gives rise to complex structures and functions. It describes processes in which a disordered system of components form organized structures as a consequence of specific, local interactions among the components themselves, without any external direction. Biological self-assembled systems, evolved over billions of years, are more intricate, more energy efficient and more functional than anything researchers have currently achieved at the nanoscale. A challenge for human designed physical self-assembled systems is to catch up with mother nature. I argue through examples that DNA is an apt material to meet this challenge. This work presents:

1. 3D self-assembled DNA nanostructures.

2. Illustrations of the simplicity and power of toehold-mediated strand displacement interactions.

3. Algorithmic constructs in the tile assembly model.

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Citation

Gopalkrishnan, Nikhil (2012). Engineering Exquisite Nanoscale Behavior with DNA. Dissertation, Duke University. Retrieved from https://hdl.handle.net/10161/5771.

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