Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.

dc.contributor.author

Goldberg, Joel S

dc.coverage.spatial

United States

dc.date.accessioned

2015-07-31T15:42:14Z

dc.date.issued

2011-02-15

dc.description.abstract

It is proposed that select oligomers of polymer d-lactic acid (PDLA) will form a stereocomplex with l-lactate in vivo, producing lactate deficiency in tumor cells. Those cancer cells that utilize transport of lactate to maintain electrical neutrality may cease to multiply or die because of lactate trapping, and those cancer cells that benefit from utilization of extracellular lactate may be impaired. Intracellular trapping of lactate produces a different physiology than inhibition of LDH because the cell loses the option of shuttling pyruvate to an alternative pathway to produce an anion. Conjugated with stains or fluorescent probes, PDLA oligomers may be an agent for the diagnosis of tissue lactate and possibly cell differentiation in biopsy specimens. Preliminary experimental evidence is presented confirming that PDLA in high concentrations is cytotoxic and that l-lactate forms a presumed stereocomplex with PDLA. Future work should be directed at isolation of biologically active oligomers of PDLA.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/21487535

dc.identifier.eissn

1177-391X

dc.identifier.uri

https://hdl.handle.net/10161/10351

dc.language

eng

dc.publisher

SAGE Publications

dc.relation.ispartof

Perspect Medicin Chem

dc.relation.isversionof

10.4137/PMC.S6229

dc.subject

PDLA

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Warburg

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cancer

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lactate

dc.title

Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.

dc.type

Journal article

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/21487535

pubs.begin-page

1

pubs.end-page

10

pubs.organisational-group

Anesthesiology

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Anesthesiology, VA Anesthesiology Service

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Clinical Science Departments

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Duke

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School of Medicine

pubs.publication-status

Published online

pubs.volume

5

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