Andexanet alfa for the reversal of Factor Xa inhibitor related anticoagulation
| dc.contributor.author | Ghadimi, K | |
| dc.contributor.author | Welsby, IJ | |
| dc.contributor.author | Levy, JH | |
| dc.contributor.author | Dombrowski, KE | |
| dc.date.accessioned | 2024-01-13T17:03:40Z | |
| dc.date.available | 2024-01-13T17:03:40Z | |
| dc.date.issued | 2016-01 | |
| dc.description.abstract | Andexanet alfa is a specific reversal agent for Factor Xa inhibitors. The molecule is a recombinant protein analog of factor Xa that binds to Factor Xa inhibitors and antithrombin:LMWH complex but does not trigger prothrombotic activity. In ex vivo, animal, and volunteer human studies, andexanet alfa (AnXa) was able to dose-dependently reverse Factor Xa inhibition and restore thrombin generation for the duration of drug administration. Further trials are underway to examine its safety and efficacy in the population of patients experiencing FXa inhibitor-related bleeding. | |
| dc.identifier.issn | 1747-4086 | |
| dc.identifier.issn | 1747-4094 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Informa UK Limited | |
| dc.relation.ispartof | Expert review of hematology | |
| dc.relation.isversionof | 10.1586/17474086.2016.1135046 | |
| dc.rights.uri | ||
| dc.subject | Animals | |
| dc.subject | Humans | |
| dc.subject | Factor Xa | |
| dc.subject | Recombinant Proteins | |
| dc.subject | Drug Evaluation, Preclinical | |
| dc.subject | Protein Binding | |
| dc.subject | Blood Coagulation | |
| dc.subject | Clinical Trials, Phase I as Topic | |
| dc.subject | Clinical Trials, Phase II as Topic | |
| dc.subject | Clinical Trials, Phase III as Topic | |
| dc.subject | Factor Xa Inhibitors | |
| dc.title | Andexanet alfa for the reversal of Factor Xa inhibitor related anticoagulation | |
| dc.type | Journal article | |
| duke.contributor.orcid | Ghadimi, K|0000-0002-9287-7541 | |
| duke.contributor.orcid | Welsby, IJ|0000-0002-2789-5612 | |
| duke.contributor.orcid | Levy, JH|0000-0003-3766-4962 | |
| pubs.begin-page | 115 | |
| pubs.end-page | 122 | |
| pubs.issue | 2 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Faculty | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Anesthesiology | |
| pubs.organisational-group | Anesthesiology, Cardiothoracic | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Medicine, Hematology | |
| pubs.organisational-group | Surgery, Cardiovascular and Thoracic Surgery | |
| pubs.publication-status | Published | |
| pubs.volume | 9 |
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