Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection
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2021-04-01
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<jats:p> βARKct, the peptide inhibitor of GRK2, improves survival and metabolic functions of cardiac-derived progenitor cells. As any benefit of stem cells in the ischemic and injured heart suggests paracrine mechanisms via secreted EVs, we investigated whether CDC-βARKct engineered EVs would show any benefit over control CDC-EVs. Compared with control EVs, βARKct-containing EVs displayed some unique beneficial properties that may be due to altered pro- and anti-inflammatory cytokines within the vesicles. </jats:p>
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Kwon, Jin-Sook, Sarah M Schumacher, Erhe Gao, J Kurt Chuprun, Jessica Ibetti, Rajika Roy, Mohsin Khan, Raj Kishore, et al. (2021). Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection. American Journal of Physiology-Heart and Circulatory Physiology, 320(4). pp. H1276–H1289. 10.1152/ajpheart.00571.2020 Retrieved from https://hdl.handle.net/10161/28935.
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Rajika Roy
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