Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection
| dc.contributor.author | Kwon, Jin-Sook | |
| dc.contributor.author | Schumacher, Sarah M | |
| dc.contributor.author | Gao, Erhe | |
| dc.contributor.author | Chuprun, J Kurt | |
| dc.contributor.author | Ibetti, Jessica | |
| dc.contributor.author | Roy, Rajika | |
| dc.contributor.author | Khan, Mohsin | |
| dc.contributor.author | Kishore, Raj | |
| dc.contributor.author | Koch, Walter J | |
| dc.date.accessioned | 2023-09-01T16:18:12Z | |
| dc.date.available | 2023-09-01T16:18:12Z | |
| dc.date.issued | 2021-04-01 | |
| dc.date.updated | 2023-09-01T16:18:12Z | |
| dc.description.abstract | <jats:p> βARKct, the peptide inhibitor of GRK2, improves survival and metabolic functions of cardiac-derived progenitor cells. As any benefit of stem cells in the ischemic and injured heart suggests paracrine mechanisms via secreted EVs, we investigated whether CDC-βARKct engineered EVs would show any benefit over control CDC-EVs. Compared with control EVs, βARKct-containing EVs displayed some unique beneficial properties that may be due to altered pro- and anti-inflammatory cytokines within the vesicles. </jats:p> | |
| dc.identifier.issn | 0363-6135 | |
| dc.identifier.issn | 1522-1539 | |
| dc.identifier.uri | ||
| dc.language | en | |
| dc.publisher | American Physiological Society | |
| dc.relation.ispartof | American Journal of Physiology-Heart and Circulatory Physiology | |
| dc.relation.isversionof | 10.1152/ajpheart.00571.2020 | |
| dc.title | Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection | |
| dc.type | Journal article | |
| duke.contributor.orcid | Roy, Rajika|0000-0001-9394-3224 | |
| duke.contributor.orcid | Koch, Walter J|0000-0002-8522-530X | |
| pubs.begin-page | H1276 | |
| pubs.end-page | H1289 | |
| pubs.issue | 4 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Surgery, Cardiovascular and Thoracic Surgery | |
| pubs.publication-status | Published | |
| pubs.volume | 320 |
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