Effects of Electrical Stimulation in the Inferior Colliculus on Frequency Discrimination by Rhesus Monkeys and Implications for the Auditory Midbrain Implant.

My patients have motivated me to be involved in clinical research. My interests spans areas such as identification of biomarkers in epilepsy, pre-surgical evaluation in epilepsy including stereoEEG as well as drugs and device trials. Given my training in biomedical engineering, I have a special interest in Neuromodulation including deep brain stimulation, responsive neurostimulation, minimally invasive device therapies as well as developing novel neuromodulation techniques for use in epilepsy care.

Our research employs engineering approaches to understand and control neural function. We work on fundamental questions and applied development in electrical stimulation of the nervous system to restore function to individuals with neurological impairment or injury.

Current projects include:
• understanding the mechanisms of and developing advanced approaches to deep brain stimulation to treat movement disorders,
• developing novel approaches to peripheral nerve electrical stimulation for restoration of bladder function, 
• understanding the mechanisms of and developing advanced approaches to spinal cord stimulation to treat chronic pain,
• understanding and controlling the cellular effects of transcranial magnetic stimulation, and
• design of novel electrodes and waveforms for selective stimulation of the nervous system.

Prof. Wilson is the Director of the Duke Hearing Center and is an Adjunct or Consulting Professor in each of three departments at Duke: Head and Neck Surgery & Communication Sciences, Biomedical Engineering, and Electrical and Computer Engineering. He has been involved in the development of the cochlear implant (CI) for four decades and is the inventor of many of the signal processing strategies used with the present-day CIs. One of his papers, in the journal Nature, is the most highly cited publication in the principal field of CIs. He also has become keenly interested in global hearing healthcare and presently is the Chair of the Lancet Commission on Hearing Loss. He or he and his teams or colleagues have been recognized with a high number of awards and honors, including the 2015 Russ Prize, “for engineering cochlear implants that allow the deaf to hear,” and the 2013 Lasker~DeBakey Award, “for the development of the modern cochlear implant – a device that bestows hearing to individuals with profound deafness.” The Russ Prize is the world’s top honor for bioengineering and the Lasker Awards are second only to the Nobel Prize in Physiology or Medicine for recognizing advances in medicine and medical science. Prof. Wilson is a recipient of the Distinguished Alumni Award from the Pratt School of Engineering at Duke (in 2007) and from the University as a whole (in 2019; the 42nd recipient of that Award). Additionally, he is a member of the USA’s National Academy of Engineering and is a Fellow of the Institute of Electrical and Electronics Engineers, the Acoustical Society of America, and the National Academy of Inventors.

Research in my laboratory concerns how sensory and motor systems work together, and how neural representations play a combined role in sensorimotor and cognitive processing (embodied cognition).

Most of our work concerns the interactions between vision and hearing. We frequently perceive visual and auditory stimuli as being bound together if they seem likely to have arisen from a common source. That's why we tend not to notice that the speakers on TV sets or in movie theatres are located beside, and not behind, the screen. Research in my laboratory is devoted to investigating the question of how the brain coordinates the information arising from the ears and eyes. Our findings challenge the historical view of the brain's sensory processing as being automatic, autonomous, and immune from outside influence. We have recently established that neurons in the auditory pathway (inferior colliculus, auditory cortex) alter their responses to sound depending on where the eyes are pointing. This finding suggests that the different sensory pathways meddle in one another's supposedly private affairs, making their respective influences felt even at very early stages of processing. The process of bringing the signals from two different sensory pathways into a common frame of reference begins at a surprisingly early point along the primary sensory pathways.