Three-dimensional super-resolution passive cavitation mapping in laser lithotripsy
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2024-01-01
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Kidney stone disease is a major public health issue. By breaking stones with repeated laser irradiation, laser lithotripsy (LL) has become the main treatment for kidney stone disease. Laser-induced cavitation is closely associated with the stone damage in LL. Monitoring the cavitation activities during LL is thus crucial to optimizing the stone damage and maximizing LL efficiency. In this study, we have developed three-dimensional super-resolution passive cavitation mapping (3D-SRPCM), in which the cavitation bubble positions can be localized with an accuracy of 40 μm, which is 1/10th of the acoustic diffraction limit. Moreover, the 3D-SRPCM reconstruction speed has been improved by 300 times by adopting a GPU-based sparse-matrix beamforming approach. Using 3D-SRPCM, we studied LL-induced cavitation activities on BegoStones, both in free space of water and confined space of a kidney phantom. The dose-dependence analysis provided by 3D-SRPCM revealed that accumulated impact pressure on the stone surface has the highest correlation with the stone damage. By providing high-resolution cavitation mapping during LL treatment, we expect that 3D-SRPCM may become a powerful tool to improve the clinical LL efficiency and patient outcome.
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Li, Daiwei, Nanchao Wang, Mucong Li, Arpit Mishra, Yuqi Tang, Tri Vu, Gaoming Xiang, Junqin Chen, et al. (2024). Three-dimensional super-resolution passive cavitation mapping in laser lithotripsy. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. pp. 1–1. 10.1109/TUFFC.2024.3443781 Retrieved from https://hdl.handle.net/10161/31499.
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Scholars@Duke
Arpit Mishra
Dr. Arpit Mishra is a Postdoctoral Associate in the Department of Mechanical Engineering and Materials Science at Duke University, USA. His research focuses on laser lithotripsy for urolithiasis treatment, combining both experimental and simulation approaches to investigate laser interactions with fluids, bubbles, and solid surfaces. He earned his PhD and M.S. in Mechanical Engineering from the Indian Institute of Technology, Kharagpur, where his dissertation centred on the dynamics of interacting cavitation bubbles. His international research experience includes fellowships as an ETH4D Visiting Researcher at ETH Zurich and a Raman Charpak Fellow at CEA/UGA Grenoble. Dr. Mishra's expertise extends to cryogenic engineering, hydrodynamic cavitation, and laser thermal safety. He has been recognized with several prestigious awards, including the Milton Van Dyke Award from the APS Division of Fluid Dynamics, the T.H.K. Frederking Space Cryogenic Workshop Student Scholarship, and the ETH4D Visiting Student Grant. His work has been featured in the 1st Traveling Gallery of Fluid Motion by the Cultural Programs of the National Academy of Sciences (CPNAS).
Michael Eric Lipkin
Pei Zhong
My research focuses on engineering and technology development with applications in the non-invasive or minimally invasive treatment of kidney stone disease via shock wave and laser lithotripsy, high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment, acoustic and optical cavitation, and ultrasound neuromodulation via sonogenetics.
We are taking an integrated and translational approach that combines fundamental research with engineering and applied technology development to devise novel and enabling ultrasonic, optical, and mechanical tools for a variety of clinical applications. We are interested in shock wave/laser-fluid-bubble-solid interaction, and resultant mechanical and thermal fields that lead to material damage and removal. We also investigate the stress response of biological cell and tissue induced by cavitation and ultrasound exposure, mediated through mechanosensitive ion channels, such as Piezo 1. Our research activities are primarily supported by NIH and through collaborations with the medical device industry.
Junjie Yao
Our mission at PI-Lab is to develop state-of-the-art photoacoustic tomography (PAT) technologies and translate PAT advances into diagnostic and therapeutic applications, especially in functional brain imaging and early cancer theranostics. PAT is the most sensitive modality for imaging rich optical absorption contrast over a wide range of spatial scales at high speed, and is one of the fastest growing biomedical imaging technologies. Using numerous endogenous and exogenous contrasts, PAT can provide high-resolution images at scales covering organelles, cells, tissues, organs, small-animal organisms, up to humans, and can reveal tissue’s anatomical, functional, metabolic, and even histologic properties, with molecular and neuronal specificity.
At PI-Lab, we develop PAT technologies with novel and advanced imaging performance, in terms of spatial resolutions, imaging speed, penetration depth, detection sensitivity, and functionality. We are interested with all aspects of PAT technology innovations, including efficient light illumination, high-sensitivity ultrasonic detection, super-resolution PAT, high-speed imaging acquisition, novel PA genetic contrast, and precise image reconstruction. On top of the technological advancements, we are devoted to serve the broad life science and medical communities with matching PAT systems for various research and clinical needs. With its unique contrast mechanism, high scalability, and inherent functional and molecular imaging capabilities, PAT is well suited for a variety of pre-clinical applications, especially for studying tumor angiogenesis, cancer hypoxia, and brain disorders; it is also a promising tool for clinical applications in procedures such as cancer screening, melanoma staging, and endoscopic examination.
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