SOCE and STIM1 signaling in the heart: Timing and location matter.

dc.contributor.author

Rosenberg, Paul

dc.contributor.author

Katz, Danielle

dc.contributor.author

Bryson, Victoria

dc.date.accessioned

2024-02-02T17:31:27Z

dc.date.available

2024-02-02T17:31:27Z

dc.date.issued

2019-01

dc.description.abstract

Store operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to striated muscle was solidified with the description of skeletal myopathies that result from mutations in STIM1 and Orai1, the two SOCE components. Here, we consider the evidence for STIM1 and SOCE in cardiac muscle and the sinoatrial node. We highlight recent studies revealing a role for STIM1 in cardiac growth in response to developmental and pathologic cues. We also review the role of STIM1 in the regulation of SOCE and Ca2+ store refilling in a non-Orai dependent manner. Finally, we discuss the importance of this pathway in ventricular cardiomyocytes where SOCE contribute to developmental growth and in pacemaker cells where SOCE likely has a fundamental to generating the cardiac rhythm.

dc.identifier

S0143-4160(18)30154-4

dc.identifier.issn

0143-4160

dc.identifier.issn

1532-1991

dc.identifier.uri

https://hdl.handle.net/10161/30121

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Cell calcium

dc.relation.isversionof

10.1016/j.ceca.2018.11.008

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

Myocardium

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Sinoatrial Node

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Myocytes, Cardiac

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Animals

dc.subject

Humans

dc.subject

Calcium

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Neoplasm Proteins

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Calcium Signaling

dc.subject

Stromal Interaction Molecule 1

dc.subject

ORAI1 Protein

dc.title

SOCE and STIM1 signaling in the heart: Timing and location matter.

dc.type

Journal article

duke.contributor.orcid

Rosenberg, Paul|0000-0002-5659-160X

pubs.begin-page

20

pubs.end-page

28

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Medicine

pubs.organisational-group

Pathology

pubs.organisational-group

Medicine, Cardiology

pubs.organisational-group

Duke Molecular Physiology Institute

pubs.publication-status

Published

pubs.volume

77

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