Cardiac cell-integrated microneedle patch for treating myocardial infarction.

dc.contributor.author

Tang, Junnan

dc.contributor.author

Wang, Jinqiang

dc.contributor.author

Huang, Ke

dc.contributor.author

Ye, Yanqi

dc.contributor.author

Su, Teng

dc.contributor.author

Qiao, Li

dc.contributor.author

Hensley, Michael Taylor

dc.contributor.author

Caranasos, Thomas George

dc.contributor.author

Zhang, Jinying

dc.contributor.author

Gu, Zhen

dc.contributor.author

Cheng, Ke

dc.date.accessioned

2022-12-03T20:16:15Z

dc.date.available

2022-12-03T20:16:15Z

dc.date.issued

2018-11

dc.date.updated

2022-12-03T20:16:11Z

dc.description.abstract

We engineered a microneedle patch integrated with cardiac stromal cells (MN-CSCs) for therapeutic heart regeneration after acute myocardial infarction (MI). To perform cell-based heart regeneration, cells are currently delivered to the heart via direct muscle injection, intravascular infusion, or transplantation of epicardial patches. The first two approaches suffer from poor cell retention, while epicardial patches integrate slowly with host myocardium. Here, we used polymeric MNs to create "channels" between host myocardium and therapeutic CSCs. These channels allow regenerative factors secreted by CSCs to be released into the injured myocardium to promote heart repair. In the rat MI model study, the application of the MN-CSC patch effectively augmented cardiac functions and enhanced angiomyogenesis. In the porcine MI model study, MN-CSC patch application was nontoxic and resulted in cardiac function protection. The MN system represents an innovative approach delivering therapeutic cells for heart regeneration.

dc.identifier

aat9365

dc.identifier.issn

2375-2548

dc.identifier.issn

2375-2548

dc.identifier.uri

https://hdl.handle.net/10161/26308

dc.language

eng

dc.publisher

American Association for the Advancement of Science (AAAS)

dc.relation.ispartof

Science advances

dc.relation.isversionof

10.1126/sciadv.aat9365

dc.subject

Cells, Cultured

dc.subject

Stromal Cells

dc.subject

Myocytes, Cardiac

dc.subject

Animals

dc.subject

Rats, Inbred WKY

dc.subject

Swine

dc.subject

Rats

dc.subject

Myocardial Infarction

dc.subject

Tissue Engineering

dc.subject

Needles

dc.subject

Regeneration

dc.subject

Microtechnology

dc.title

Cardiac cell-integrated microneedle patch for treating myocardial infarction.

dc.type

Journal article

duke.contributor.orcid

Su, Teng|0000-0001-7888-0763

pubs.begin-page

eaat9365

pubs.issue

11

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Medicine

pubs.organisational-group

Medicine, Cardiology

pubs.publication-status

Published

pubs.volume

4

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Cardiac cell-integrated microneedle patch for treating myocardial infarction.pdf
Size:
1.69 MB
Format:
Adobe Portable Document Format
Description:
Published version