Heritability estimates of endophenotypes of long and health life: the Long Life Family Study.

Matteini, Amy M

Fallin, M Daniele

Kammerer, Candace M

Schupf, Nicole

Yashin, Anatoli I

Christensen, Kaare

Arbeev, Konstantin G

Barr, Graham

Mayeux, Richard

Newman, Anne B

Walston, Jeremy D

United States

2017-06-07T19:37:50Z

2017-06-07T19:37:50Z

2010-12

BACKGROUND: Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span. METHODS: As part of phenotype development efforts for the Long Life Family Study, endophenotypes that represent exceptional survival were identified and heritability estimates were calculated. Principal components (PCs) analysis was carried out using 28 physiologic measurements from five trait domains (cardiovascular, cognition, physical function, pulmonary, and metabolic). RESULTS: The five most dominant PCs accounted for 50% of underlying trait variance. The first PC (PC1), which consisted primarily of poor pulmonary and physical function, represented 14.3% of the total variance and had an estimated heritability of 39%. PC2 consisted of measures of good metabolic and cardiovascular function with an estimated heritability of 27%. PC3 was made up of cognitive measures (h(2) = 36%). PC4 and PC5 contained measures of blood pressure and cholesterol, respectively (h(2) = 25% and 16%). CONCLUSIONS: These PCs analysis-derived endophenotypes may be used in genetic association studies to help identify underlying genetic mechanisms that drive exceptional survival in this and other populations.

https://www.ncbi.nlm.nih.gov/pubmed/20813793

glq154

1758-535X

https://hdl.handle.net/10161/14882

eng

Oxford University Press (OUP)

J Gerontol A Biol Sci Med Sci

10.1093/gerona/glq154

Cardiovascular Physiological Phenomena

Cholesterol, HDL

Cognition

Cohort Studies

Endophenotypes

Forced Expiratory Volume

Genetic Variation

Hand Strength

Health Status

Humans

Longevity

Lung

Metabolism

Motor Activity

National Institute on Aging (U.S.)

Principal Component Analysis

Quantitative Trait, Heritable

United States

Waist Circumference

Heritability estimates of endophenotypes of long and health life: the Long Life Family Study.

Journal article

Arbeev, Konstantin G|0000-0002-4195-7832

https://www.ncbi.nlm.nih.gov/pubmed/20813793

1375

1379

12

Center for Population Health & Aging

Duke

Duke Cancer Institute

Duke Population Research Center

Duke Population Research Institute

Institutes and Centers

Institutes and Provost's Academic Units

Sanford School of Public Policy

School of Medicine

Social Science Research Institute

Staff

University Institutes and Centers

Published

65