Glucose-responsive polymer brushes for microcantilever sensing
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2010-06-08
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Glucose responsive polymer brushes were synthesized on gold substrates and microcantilever arrays. The response properties of these brushes were evaluated by exposing them to different glucose concentrations for a range of pH values. This work demonstrates the potential for polymer brush-functionalized micromechanical cantilevers as glucose detectors. Furthermore, the work demonstrates that stimulus-responsive polymer brushes on micromechanical cantilevers have a significantly larger bending response due to glucose binding compared with self-assembled monolayers. © The Royal Society of Chemistry 2010.
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Chen, T, DP Chang, T Liu, R Desikan, R Datar, T Thundat, R Berger, S Zauscher, et al. (2010). Glucose-responsive polymer brushes for microcantilever sensing. Journal of Materials Chemistry, 20(17). pp. 3391–3395. 10.1039/b925583d Retrieved from https://hdl.handle.net/10161/4121.
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Scholars@Duke
Stefan Zauscher
My research lies at the intersection of surface and colloid science, polymer materials engineering, and biointerface science, with four central areas of focus:
- Fabrication, manipulation and characterization of stimulus-responsive biomolecular and bio-inspired polymeric nanostructures on surfaces;
- Nanotechnology of soft-wet materials and hybrid biological/non-biological microdevices;
- Receptor-ligand interactions relevant to the diagnostics of infectious diseases;
- Friction of soft-wet materials, specifically the role of glycoproteins on friction in diarthroidal joints.
These four broad lines of inquiry deal with fundamental behaviors of soft-wet materials on surfaces and interfaces. The design and fabrication of these interfaces using "smart" polymeric and biomolecular nanostructures, and the characterization of the resulting structures, are critically important for the development of biomolecular sensors and devices and for bioinspired materials. Key approaches and tools I use in my research are: bottom-up organization on the molecular scale, through self-assembly, in-situ polymerization, and manipulation of intermolecular interactions; topdown fabrication, through scanning probe nanolithography; stimulus-responsive polymers; molecular recognition; and new approaches to sensing and manipulation. This research supports Duke's Pratt School of Engineering strategic initiative to expand research in soft-wet Materials Science.
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.