Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation.

Hijazi, Ziad

Granger, Christopher B

Hohnloser, Stefan H

Westerbergh, Johan

Lindbäck, Johan

Alexander, John H

Keltai, Matyas

Parkhomenko, Alexander

López-Sendón, José L

Lopes, Renato D

Siegbahn, Agneta

Wallentin, Lars

2021-05-10T18:08:14Z

2021-05-10T18:08:14Z

2020-09

2021-05-10T18:08:12Z

Background We compared different methods of estimated glomerular filtration rate (eGFR) and their association with cardiovascular death and major bleeding in 14 980 patients with atrial fibrillation in the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial. Methods and Results eGFR was calculated using equations based on creatinine (Cockcroft-Gault, Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) and/or cystatin C (CKD-EPI_CysC and CKD-EPI_{CysC+Creatinine}). These 5 eGFR equations, as well as the individual variables that are used in these equations, were assessed for correlation and discriminatory ability for cardiovascular death and major bleeding. The median age was 70.0 years, and 35.6% were women. The median eGFR was highest with Cockcroft-Gault (74.1 mL/min) and CKD-EPI_CysC (74.2 mL/min), and lowest with Modification of Diet in Renal Disease (66.5 mL/min). Correlation between methods ranged from 0.49 (Cockroft-Gault and CKD-EPI_CysC) to 0.99 (Modification of Diet in Renal Disease and CKD-EPI). Among the eGFR equations, those based on cystatin C yielded the highest C indices for cardiovascular death and major bleeding: 0.628 (CKD-EPI_CysC) and 0.612 (CKD-EPI_{CysC+Creatinine}), respectively. A model based on the variables within the different eGFR equations (age, sex, weight, creatinine, and cystatin C) yielded the highest discriminatory value for both outcomes, with a C index of 0.673 and 0.656, respectively. Conclusions In patients with atrial fibrillation on anticoagulation, correlation between eGFR calculated using different methods varied substantially. Cystatin C-based eGFRs seem to provide the most robust information for predicting death and bleeding. A model based on the individual variables within the eGFR equations, however, provided the highest discriminatory value. Our findings may help refine risk stratification in patients with atrial fibrillation and define how renal function should be determined in future atrial fibrillation studies. Registration URL: https://www.clini​caltr​ials.gov; Unique identifier: NCT00412984.

2047-9980

2047-9980

https://hdl.handle.net/10161/22864

eng

Ovid Technologies (Wolters Kluwer Health)

Journal of the American Heart Association

10.1161/jaha.120.017155

Kidney

Humans

Cardiovascular Diseases

Atrial Fibrillation

Hemorrhage

Anticoagulants

Glomerular Filtration Rate

Risk Assessment

Aged

Female

Male

Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation.

Journal article

Granger, Christopher B|0000-0002-0045-3291

Alexander, John H|0000-0002-1444-2462

Lopes, Renato D|0000-0003-2999-4961

e017155

18

School of Medicine

Duke Clinical Research Institute

Medicine, Cardiology

Duke

Institutes and Centers

Medicine

Clinical Science Departments

Nursing

School of Nursing

Published

9