Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight.

Abstract

BACKGROUND: Cadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals may mitigate exposure, data are inconsistent. This study sought to evaluate the relationship between toxic metals, nutrient combinations and birthweight among 275 mother-child pairs. METHODS: Non-essential metals, Cd, Pb, As, and essential metals, iron (Fe), zinc (Zn), selenium (Se), copper (Cu), calcium (Ca), magnesium (Mg), and manganese (Mn) were measured in maternal whole blood obtained during the first trimester using inductively coupled plasma mass spectrometry. Folate concentrations were measured by microbial assay. Birthweight was obtained from medical records. We used quantile regression to evaluate the association between toxic metals and nutrients due to their underlying wedge-shaped relationship. Ordinary linear regression was used to evaluate associations between birth weight and toxic metals. RESULTS: After multivariate adjustment, the negative association between Pb or Cd and a combination of Fe, Se, Ca and folate was robust, persistent and dose-dependent (p < 0.05). However, a combination of Zn, Cu, Mn and Mg was positively associated with Pb and Cd levels. While prenatal blood Cd and Pb were also associated with lower birthweight. Fe, Se, Ca and folate did not modify these associations. CONCLUSION: Small sample size and cross-sectional design notwithstanding, the robust and persistent negative associations between some, but not all, nutrient combinations with these ubiquitous environmental contaminants suggest that only some recommended nutrient combinations may mitigate toxic metal exposure in chronically exposed populations. Larger longitudinal studies are required to confirm these findings.

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Published Version (Please cite this version)

10.1186/s12889-017-4225-8

Publication Info

Luo, Yiwen, Lauren E McCullough, Jung-Ying Tzeng, Thomas Darrah, Avner Vengosh, Rachel L Maguire, Arnab Maity, Carmen Samuel-Hodge, et al. (2017). Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight. BMC Public Health, 17(1). p. 354. 10.1186/s12889-017-4225-8 Retrieved from https://hdl.handle.net/10161/14635.

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Scholars@Duke

Vengosh

Avner Vengosh

Nicholas Distinguished Professor of Environmental Quality

Avner Vengosh is a Distinguished Professor and Nicholas Chair of Environmental Quality at the Nicholas School of the Environment. He is the chair of the Division of  Earth and Climate Sciences. Professor Vengosh and his team have studied the energy-water nexus, conducting pioneer research on the impact of hydraulic fracturing and coal ash disposal on the quantity and quality of water resources in the U.S. and China. He has also investigated the sources and mechanisms of water contamination in numerous countries across the globe, including salinity and radioactivity in the Middle East, uranium in India, fluoride in Eastern Africa, arsenic in Vietnam, and hexavalent chromium in North Carolina and China. As part of these studies, his team has developed novel geochemical and isotopic tracers that are used as fingerprints to delineate the sources of water contamination and evaluate potential risks for human health. Currently, his team is engaged in studying phosphate rocks geochemistry and the impact of fertilizers on soil and water quality, unconventional sources of critical raw materials, and potential environmental effects of lithium mining from hard rocks and brines. He is a Fellow of the Geological Society of America (GSA) and International Association of Geochemistry (IAGC). In 2019, 2020 and 2021 he was recognized as one of the Web of Science Highly Cited Researchers. He serves as an Editor of GeoHealth and on the editorial board of the journal Environmental Science and Technology. He has published 171 scientific papers in leading international journals. His recent cross-disciplinary book “Water Quality Impacts of the Energy-Water Nexus” (Cambridge University Press, 2020) provides an integrated assessment of the different scientific and policy tools around the energy-water nexus. It focuses on how water use, and wastewater and waste solids produced from fossil fuel energy production affect water quality and quantity. Summarizing cutting edge research, the book describes the scientific methods for detecting contamination sources in the context of policy and regulations.

Murphy

Susan Kay Murphy

Associate Professor in Obstetrics and Gynecology

Dr. Murphy is a tenured Associate Professor in the Department of Obstetrics and Gynecology and serves as Chief of the Division of Reproductive Sciences. As a molecular biologist with training in human epigenetics, her research interests are largely centered around the role of epigenetic modifications in health and disease. 

Dr. Murphy has ongoing projects on gynecologic malignancies, including approaches to eradicate ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease. Dr. Murphy is actively involved in many collaborative projects relating to the Developmental Origins of Health and Disease (DOHaD).

Her lab is currently working on preconception environmental exposures in males, particularly on the impact of cannabis on the sperm epigenome and the potential heritability of these effects. They are also studying the epigenetic and health effects of in utero exposures, with primary focus on children from the Newborn Epigenetics STudy (NEST), a pregnancy cohort she co-founded who were recruited from central North Carolina between 2005 and 2011. Dr. Murphy and her colleagues continue to follow NEST children to determine relationships between prenatal exposures and later health outcomes.


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