Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing.

dc.contributor.author

Abril, Maria K

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Barnett, Adam S

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Wegermann, Kara

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Fountain, Eric

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Strand, Andrew

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Heyman, Benjamin M

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Blough, Britton A

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Swaminathan, Aparna C

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Sharma-Kuinkel, Batu

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Ruffin, Felicia

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Alexander, Barbara D

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McCall, Chad M

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Costa, Sylvia F

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Arcasoy, Murat O

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Hong, David K

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Blauwkamp, Timothy A

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Kertesz, Michael

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Fowler, Vance G

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Kraft, Bryan D

dc.coverage.spatial

United States

dc.date.accessioned

2017-01-01T19:54:17Z

dc.date.issued

2016-09

dc.description.abstract

We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/27704003

dc.identifier

ofw144

dc.identifier.uri

https://hdl.handle.net/10161/13301

dc.language

eng

dc.publisher

Oxford University Press (OUP)

dc.relation.ispartof

Open Forum Infect Dis

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10.1093/ofid/ofw144

dc.subject

high-throughput nucleotide sequencing

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microbiological techniques

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sepsis/diagnosis

dc.title

Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing.

dc.type

Journal article

duke.contributor.orcid

Wegermann, Kara|0000-0002-1024-9040

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Swaminathan, Aparna C|0000-0002-0003-9971

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Ruffin, Felicia|0000-0003-2176-6462

duke.contributor.orcid

Alexander, Barbara D|0000-0001-5868-0529

duke.contributor.orcid

Fowler, Vance G|0000-0002-8048-0897

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/27704003

pubs.begin-page

ofw144

pubs.issue

3

pubs.organisational-group

Basic Science Departments

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Clinical Science Departments

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Duke

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Duke Clinical Research Institute

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Institutes and Centers

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Medicine

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Medicine, Infectious Diseases

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Medicine, Pulmonary, Allergy, and Critical Care Medicine

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Molecular Genetics and Microbiology

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School of Medicine

pubs.publication-status

Published online

pubs.volume

3

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