Seven unconfirmed ideas to improve future ICU practice.

dc.contributor.author

Marini, John J

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De Backer, Daniel

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Ince, Can

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Singer, Mervyn

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Van Haren, Frank

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Westphal, Martin

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Wischmeyer, Paul

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England

dc.date.accessioned

2018-01-17T18:21:47Z

dc.date.available

2018-01-17T18:21:47Z

dc.date.issued

2017-12-28

dc.description.abstract

With imprecise definitions, inexact measurement tools, and flawed study execution, our clinical science often lags behind bedside experience and simply documents what appear to be the apparent faults or validity of ongoing practices. These impressions are later confirmed, modified, or overturned by the results of the next trial. On the other hand, insights that stem from the intuitions of experienced clinicians, scientists and educators-while often neglected-help place current thinking into proper perspective and occasionally point the way toward formulating novel hypotheses that direct future research. Both streams of information and opinion contribute to progress. In this paper we present a wide-ranging set of unproven 'out of the mainstream' ideas of our FCCM faculty, each with a defensible rationale and holding clear implications for altering bedside management. Each proposition was designed deliberately to be provocative so as to raise awareness, stimulate new thinking and initiate lively dialog.

dc.identifier

https://www.ncbi.nlm.nih.gov/pubmed/29297400

dc.identifier

10.1186/s13054-017-1904-x

dc.identifier.eissn

1466-609X

dc.identifier.uri

https://hdl.handle.net/10161/15998

dc.language

eng

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Springer Science and Business Media LLC

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Crit Care

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10.1186/s13054-017-1904-x

dc.subject

Adaptive clinical trials

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Melatonin

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Metabolic monitoring

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Microcirculation

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Personalized medicine

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Resuscitation

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Sepsis

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Shock

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Ventilator-induced lung injury

dc.title

Seven unconfirmed ideas to improve future ICU practice.

dc.type

Journal article

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/29297400

pubs.begin-page

315

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Suppl 3

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Anesthesiology

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Anesthesiology, Critical Care Medicine

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Clinical Science Departments

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Duke

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Duke Clinical Research Institute

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Institutes and Centers

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School of Medicine

pubs.publication-status

Published online

pubs.volume

21

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