Pills of PTEN? In and out for tumor suppression.

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2013-10

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Abstract

The tumor-suppressive activity of PTEN has always been attributed to its endogenous intracellular function. Recently two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment for uptake by recipient cells, and functions as a tumor suppressor in a cell non-autonomous manner.

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Published Version (Please cite this version)

10.1038/cr.2013.103

Publication Info

Papa, Antonella, Ming Chen and Pier Paolo Pandolfi (2013). Pills of PTEN? In and out for tumor suppression. Cell research, 23(10). pp. 1155–1156. 10.1038/cr.2013.103 Retrieved from https://hdl.handle.net/10161/20385.

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Scholars@Duke

Chen

Ming Chen

Associate Professor in Pathology

Our laboratory is interested in understanding the molecular and genetic events underlying cancer progression and metastasis. The focus of our work is a series of genetically engineered mouse models that faithfully recapitulate human disease. Using a combination of mouse genetics, omics technologies, cross-species analyses and in vitro approaches, we aim to identify cancer cell–intrinsic and –extrinsic mechanisms driving metastatic cancer progression, with a long–term goal of developing new therapeutic strategies for preventing and treating metastatic disease. 


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