Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches.
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2023-01
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Abstract
Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses depend on host factors for the process of viral infection and replication. A better understanding of the dynamic interplay between viral pathogens and host cells, as well as identifying of virus-host dependencies, offers valuable insights into disease mechanisms and informs the development of effective therapeutic strategies against viral infections. This review delves into the key host factors that facilitate or hinder SARS-CoV-2 infection and replication, as identified by CRISPR/Cas9-based screening platforms. Furthermore, we explore CRISPR/Cas13-based gene therapy strategies aimed at targeting these host factors to inhibit viral infection, with the ultimate goal of eradicating SARS-CoV-2 and preventing and treating related coronaviruses for future outbreaks.
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Cui, Zhifen, Hongyan Wang, Yizhou Dong, Shan-Lu Liu and Qianben Wang (2023). Deciphering and targeting host factors to counteract SARS-CoV-2 and coronavirus infections: insights from CRISPR approaches. Frontiers in genome editing, 5. p. 1231656. 10.3389/fgeed.2023.1231656 Retrieved from https://hdl.handle.net/10161/29310.
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Scholars@Duke
Qianben Wang
Dr. Wang's laboratory is primarily focused on understanding the transcriptional and epigenetic mechanisms that drive the progression of hormone-dependent cancers. Additionally, they investigate the role of host proteases in coronavirus infection. Their recent studies aim to combine CRISPR/Cas13 technologies with nanotechnology to target undruggable transcription factors in cancers and host proteases for controlling infections caused by SARS-CoV-2 and related coronaviruses.
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