B cells in rheumatoid synovitis.
dc.contributor.author | Weyand, Cornelia M | |
dc.contributor.author | Seyler, Thorsten M | |
dc.contributor.author | Goronzy, Jörg J | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2015-08-12T18:09:20Z | |
dc.date.issued | 2005 | |
dc.description.abstract | In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B cells support rheumatoid disease through other mechanisms. A critical element of rheumatoid synovitis is the process of ectopic lymphoid neogenesis, with highly efficient lymphoid architectures established in a nonlymphoid tissue site. Rheumatoid synovitis recapitulates the pathways of lymph node formation, and B cells play a key role in this process. Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals. | |
dc.identifier | ||
dc.identifier | ar1737 | |
dc.identifier.eissn | 1478-6362 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartof | Arthritis Res Ther | |
dc.relation.isversionof | 10.1186/ar1737 | |
dc.subject | Animals | |
dc.subject | Arthritis, Rheumatoid | |
dc.subject | B-Lymphocytes | |
dc.subject | Humans | |
dc.subject | Synovial Membrane | |
dc.subject | Synovitis | |
dc.title | B cells in rheumatoid synovitis. | |
dc.type | Journal article | |
duke.contributor.orcid | Seyler, Thorsten M|0000-0003-1157-132X | |
pubs.author-url | ||
pubs.begin-page | S9 | |
pubs.end-page | 12 | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Orthopaedics | |
pubs.organisational-group | School of Medicine | |
pubs.publication-status | Published | |
pubs.volume | 7 Suppl 3 |
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