B cells in rheumatoid synovitis.

dc.contributor.author

Weyand, Cornelia M

dc.contributor.author

Seyler, Thorsten M

dc.contributor.author

Goronzy, Jörg J

dc.coverage.spatial

England

dc.date.accessioned

2015-08-12T18:09:20Z

dc.date.issued

2005

dc.description.abstract

In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B cells support rheumatoid disease through other mechanisms. A critical element of rheumatoid synovitis is the process of ectopic lymphoid neogenesis, with highly efficient lymphoid architectures established in a nonlymphoid tissue site. Rheumatoid synovitis recapitulates the pathways of lymph node formation, and B cells play a key role in this process. Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/15960820

dc.identifier

ar1737

dc.identifier.eissn

1478-6362

dc.identifier.uri

https://hdl.handle.net/10161/10370

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

Arthritis Res Ther

dc.relation.isversionof

10.1186/ar1737

dc.subject

Animals

dc.subject

Arthritis, Rheumatoid

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B-Lymphocytes

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Humans

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Synovial Membrane

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Synovitis

dc.title

B cells in rheumatoid synovitis.

dc.type

Journal article

duke.contributor.orcid

Seyler, Thorsten M|0000-0003-1157-132X

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/15960820

pubs.begin-page

S9

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12

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Duke

pubs.organisational-group

Orthopaedics

pubs.organisational-group

School of Medicine

pubs.publication-status

Published

pubs.volume

7 Suppl 3

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