The genetic architecture of the human cerebral cortex.

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dc.contributor.author

Grasby, Katrina L

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Jahanshad, Neda

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Painter, Jodie N

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Colodro-Conde, Lucía

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Bralten, Janita

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Hibar, Derrek P

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Lind, Penelope A

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Pizzagalli, Fabrizio

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Ching, Christopher RK

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McMahon, Mary Agnes B

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Shatokhina, Natalia

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Zsembik, Leo CP

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Thomopoulos, Sophia I

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Zhu, Alyssa H

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Strike, Lachlan T

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Agartz, Ingrid

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Alhusaini, Saud

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Almeida, Marcio AA

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Alnæs, Dag

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Amlien, Inge K

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Andersson, Micael

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Ard, Tyler

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Armstrong, Nicola J

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Ashley-Koch, Allison

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Atkins, Joshua R

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Bernard, Manon

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Brouwer, Rachel M

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Buimer, Elizabeth EL

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Bülow, Robin

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Bürger, Christian

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Cannon, Dara M

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Chakravarty, Mallar

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Chen, Qiang

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Cheung, Joshua W

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Couvy-Duchesne, Baptiste

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Dale, Anders M

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Dalvie, Shareefa

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de Araujo, Tânia K

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de Zubicaray, Greig I

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de Zwarte, Sonja MC

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den Braber, Anouk

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Doan, Nhat Trung

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Dohm, Katharina

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Ehrlich, Stefan

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Engelbrecht, Hannah-Ruth

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Erk, Susanne

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Fan, Chun Chieh

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Fedko, Iryna O

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Foley, Sonya F

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Ford, Judith M

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Fukunaga, Masaki

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Garrett, Melanie E

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Ge, Tian

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Giddaluru, Sudheer

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Goldman, Aaron L

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Green, Melissa J

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Groenewold, Nynke A

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Grotegerd, Dominik

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Gurholt, Tiril P

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Gutman, Boris A

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Hansell, Narelle K

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Harris, Mathew A

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Harrison, Marc B

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Haswell, Courtney C

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Hauser, Michael

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Herms, Stefan

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Heslenfeld, Dirk J

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Ho, New Fei

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Hoehn, David

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Hoffmann, Per

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Holleran, Laurena

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Hoogman, Martine

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Hottenga, Jouke-Jan

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Ikeda, Masashi

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Janowitz, Deborah

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Jansen, Iris E

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Jia, Tianye

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Jockwitz, Christiane

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Kanai, Ryota

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Karama, Sherif

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Kasperaviciute, Dalia

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Kaufmann, Tobias

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Kelly, Sinead

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Kikuchi, Masataka

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Klein, Marieke

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Knapp, Michael

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Knodt, Annchen R

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Krämer, Bernd

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Lam, Max

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Lancaster, Thomas M

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Lee, Phil H

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Lett, Tristram A

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Lewis, Lindsay B

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Lopes-Cendes, Iscia

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Luciano, Michelle

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Macciardi, Fabio

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Marquand, Andre F

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Mathias, Samuel R

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Melzer, Tracy R

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Milaneschi, Yuri

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Mirza-Schreiber, Nazanin

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Moreira, Jose CV

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Mühleisen, Thomas W

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Müller-Myhsok, Bertram

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Najt, Pablo

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Nakahara, Soichiro

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Nho, Kwangsik

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Olde Loohuis, Loes M

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Orfanos, Dimitri Papadopoulos

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Pearson, John F

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Pitcher, Toni L

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Pütz, Benno

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Quidé, Yann

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Ragothaman, Anjanibhargavi

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Rashid, Faisal M

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Reay, William R

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Redlich, Ronny

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Reinbold, Céline S

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Repple, Jonathan

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Richard, Geneviève

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Riedel, Brandalyn C

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Risacher, Shannon L

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Rocha, Cristiane S

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Mota, Nina Roth

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Salminen, Lauren

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Saremi, Arvin

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Saykin, Andrew J

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Schlag, Fenja

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Schmaal, Lianne

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Schofield, Peter R

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Secolin, Rodrigo

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Shapland, Chin Yang

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Shen, Li

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Shin, Jean

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Shumskaya, Elena

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Sønderby, Ida E

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Sprooten, Emma

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Tansey, Katherine E

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Teumer, Alexander

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Thalamuthu, Anbupalam

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Tordesillas-Gutiérrez, Diana

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Turner, Jessica A

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Uhlmann, Anne

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Vallerga, Costanza Ludovica

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van der Meer, Dennis

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van Donkelaar, Marjolein MJ

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van Eijk, Liza

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van Erp, Theo GM

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van Haren, Neeltje EM

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van Rooij, Daan

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van Tol, Marie-José

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Veldink, Jan H

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Verhoef, Ellen

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Walton, Esther

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Wang, Mingyuan

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Wang, Yunpeng

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Wardlaw, Joanna M

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Wen, Wei

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Westlye, Lars T

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Whelan, Christopher D

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Witt, Stephanie H

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Wittfeld, Katharina

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Wolf, Christiane

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Wolfers, Thomas

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Wu, Jing Qin

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Yasuda, Clarissa L

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Zaremba, Dario

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Zhang, Zuo

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Zwiers, Marcel P

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Artiges, Eric

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Assareh, Amelia A

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Ayesa-Arriola, Rosa

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Belger, Aysenil

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Brandt, Christine L

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Brown, Gregory G

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Cichon, Sven

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Curran, Joanne E

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Davies, Gareth E

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Degenhardt, Franziska

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Dennis, Michelle F

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Dietsche, Bruno

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Djurovic, Srdjan

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Doherty, Colin P

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Espiritu, Ryan

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Garijo, Daniel

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Gil, Yolanda

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Gowland, Penny A

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Green, Robert C

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Häusler, Alexander N

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Heindel, Walter

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Ho, Beng-Choon

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Hoffmann, Wolfgang U

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Holsboer, Florian

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Homuth, Georg

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Hosten, Norbert

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Jack, Clifford R

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Jang, MiHyun

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Jansen, Andreas

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Kimbrel, Nathan A

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Kolskår, Knut

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Koops, Sanne

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Krug, Axel

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Lim, Kelvin O

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Luykx, Jurjen J

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Mathalon, Daniel H

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Mather, Karen A

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Mattay, Venkata S

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Matthews, Sarah

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Mayoral Van Son, Jaqueline

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McEwen, Sarah C

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Melle, Ingrid

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Morris, Derek W

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Mueller, Bryon A

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Nauck, Matthias

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Nordvik, Jan E

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Nöthen, Markus M

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O'Leary, Daniel S

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Opel, Nils

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Martinot, Marie-Laure Paillère

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Pike, G Bruce

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Preda, Adrian

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Quinlan, Erin B

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Rasser, Paul E

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Ratnakar, Varun

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Reppermund, Simone

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Steen, Vidar M

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Tooney, Paul A

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Torres, Fábio R

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Veltman, Dick J

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Voyvodic, James T

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Whelan, Robert

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White, Tonya

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Yamamori, Hidenaga

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Adams, Hieab HH

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Bis, Joshua C

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Debette, Stephanie

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Decarli, Charles

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Fornage, Myriam

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Gudnason, Vilmundur

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Hofer, Edith

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Ikram, M Arfan

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Launer, Lenore

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Longstreth, WT

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Lopez, Oscar L

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Mazoyer, Bernard

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Mosley, Thomas H

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Roshchupkin, Gennady V

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Satizabal, Claudia L

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Schmidt, Reinhold

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Seshadri, Sudha

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Yang, Qiong

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Alzheimer’s Disease Neuroimaging Initiative

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CHARGE Consortium

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EPIGEN Consortium

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IMAGEN Consortium

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SYS Consortium

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Parkinson’s Progression Markers Initiative

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Alvim, Marina KM

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Ames, David

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Anderson, Tim J

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Andreassen, Ole A

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Arias-Vasquez, Alejandro

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Bastin, Mark E

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Baune, Bernhard T

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Beckham, Jean C

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Blangero, John

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Boomsma, Dorret I

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Brodaty, Henry

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Brunner, Han G

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Buckner, Randy L

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Buitelaar, Jan K

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Bustillo, Juan R

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Cahn, Wiepke

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Cairns, Murray J

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Calhoun, Vince

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Carr, Vaughan J

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Caseras, Xavier

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Caspers, Svenja

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Cavalleri, Gianpiero L

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Cendes, Fernando

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Corvin, Aiden

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Crespo-Facorro, Benedicto

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Dalrymple-Alford, John C

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Dannlowski, Udo

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de Geus, Eco JC

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Deary, Ian J

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Delanty, Norman

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Depondt, Chantal

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Desrivières, Sylvane

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Donohoe, Gary

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Espeseth, Thomas

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Fernández, Guillén

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Fisher, Simon E

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Flor, Herta

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Forstner, Andreas J

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Francks, Clyde

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Franke, Barbara

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Glahn, David C

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Gollub, Randy L

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Grabe, Hans J

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Gruber, Oliver

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Håberg, Asta K

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Hariri, Ahmad R

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Hartman, Catharina A

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Hashimoto, Ryota

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Heinz, Andreas

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Henskens, Frans A

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Hillegers, Manon HJ

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Hoekstra, Pieter J

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Holmes, Avram J

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Hong, L Elliot

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Hopkins, William D

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Hulshoff Pol, Hilleke E

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Jernigan, Terry L

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Jönsson, Erik G

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Kahn, René S

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Kennedy, Martin A

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Kircher, Tilo TJ

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Kochunov, Peter

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Kwok, John BJ

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Le Hellard, Stephanie

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Loughland, Carmel M

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Martin, Nicholas G

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Martinot, Jean-Luc

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McDonald, Colm

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McMahon, Katie L

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Meyer-Lindenberg, Andreas

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Michie, Patricia T

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Morey, Rajendra A

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Mowry, Bryan

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Nyberg, Lars

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Oosterlaan, Jaap

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Ophoff, Roel A

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Pantelis, Christos

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Paus, Tomas

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Pausova, Zdenka

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Penninx, Brenda WJH

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Polderman, Tinca JC

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Posthuma, Danielle

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Rietschel, Marcella

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Roffman, Joshua L

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Rowland, Laura M

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Sachdev, Perminder S

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Sämann, Philipp G

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Schall, Ulrich

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Schumann, Gunter

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Scott, Rodney J

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Sim, Kang

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Sisodiya, Sanjay M

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Smoller, Jordan W

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Sommer, Iris E

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St Pourcain, Beate

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Stein, Dan J

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Toga, Arthur W

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Trollor, Julian N

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Van der Wee, Nic JA

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van 't Ent, Dennis

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Völzke, Henry

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Walter, Henrik

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Weber, Bernd

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Weinberger, Daniel R

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Wright, Margaret J

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Zhou, Juan

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Stein, Jason L

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Thompson, Paul M

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Medland, Sarah E

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Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group

dc.date.accessioned

2020-04-01T15:00:49Z

dc.date.available

2020-04-01T15:00:49Z

dc.date.issued

2020-03

dc.date.updated

2020-04-01T15:00:47Z

dc.description.abstract

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.

dc.identifier

367/6484/eaay6690

dc.identifier.issn

0036-8075

dc.identifier.issn

1095-9203

dc.identifier.uri

https://hdl.handle.net/10161/20340

dc.language

eng

dc.publisher

American Association for the Advancement of Science (AAAS)

dc.relation.ispartof

Science (New York, N.Y.)

dc.relation.isversionof

10.1126/science.aay6690

dc.subject

Alzheimer’s Disease Neuroimaging Initiative

dc.subject

CHARGE Consortium

dc.subject

EPIGEN Consortium

dc.subject

IMAGEN Consortium

dc.subject

SYS Consortium

dc.subject

Parkinson’s Progression Markers Initiative

dc.subject

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group

dc.title

The genetic architecture of the human cerebral cortex.

dc.type

Journal article

duke.contributor.orcid

Ashley-Koch, Allison|0000-0001-5409-9155

duke.contributor.orcid

Kimbrel, Nathan A|0000-0001-7218-1005

duke.contributor.orcid

Beckham, Jean C|0000-0001-8746-8949

pubs.begin-page

eaay6690

pubs.end-page

eaay6690

pubs.issue

6484

pubs.organisational-group

School of Medicine

pubs.organisational-group

Center for Child and Family Policy

pubs.organisational-group

Duke Molecular Physiology Institute

pubs.organisational-group

Biostatistics & Bioinformatics

pubs.organisational-group

Molecular Genetics and Microbiology

pubs.organisational-group

Duke Institute for Brain Sciences

pubs.organisational-group

Medicine, Nephrology

pubs.organisational-group

Duke

pubs.organisational-group

Sanford School of Public Policy

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

University Institutes and Centers

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

Medicine

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Medicine, Medical Genetics

pubs.organisational-group

Duke-UNC Center for Brain Imaging and Analysis

pubs.organisational-group

Psychiatry & Behavioral Sciences, Translational Neuroscience

pubs.organisational-group

Psychiatry & Behavioral Sciences

pubs.organisational-group

Psychiatry & Behavioral Sciences, Behavioral Medicine

pubs.publication-status

Published

pubs.volume

367

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