Direct carbon-carbon bond formation via soft enolization: aldol addition of alpha-halogenated thioesters

Thumbnail Image
View / Download576.11 KB

Date

2011

Authors

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

384
views
467
downloads

Citation Stats

Abstract

alpha-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr2 center dot OEt2 and i-Pr2NEt to produce alpha-halo-beta-hydroxy thioesters.

Type

Other article

Department

Description

Provenance

Subjects

darzens, acids, triethylamine, 1,3-diketones, condensation, ketones, facile, esters, chemistry, multidisciplinary

Citation

Yost,Julianne M.;Alfie,Rachel J.;Tarsis,Emily M.;Chong,Insun;Coltart,Don M.. 2011. Direct carbon-carbon bond formation via soft enolization: aldol addition of alpha-halogenated thioesters. Chemical Communications 47(1): 571-572.

Permalink

https://hdl.handle.net/10161/4130

Published Version (Please cite this version)

10.1039/c0cc02345k

Collections

Scholarly Articles
Full item page

Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.