Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA).
dc.contributor.author | Chatterjee, Ranee | |
dc.contributor.author | Zelnick, Leila | |
dc.contributor.author | Mukamal, Kenneth J | |
dc.contributor.author | Nettleton, Jennifer A | |
dc.contributor.author | Kestenbaum, Bryan R | |
dc.contributor.author | Siscovick, David S | |
dc.contributor.author | Ix, Joachim H | |
dc.contributor.author | Tracy, Russell | |
dc.contributor.author | Hoofnagle, Andrew N | |
dc.contributor.author | Svetkey, Laura P | |
dc.contributor.author | Edelman, David | |
dc.contributor.author | de Boer, Ian H | |
dc.contributor.editor | Schnabel, Renate B | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2016-08-01T17:10:26Z | |
dc.date.issued | 2016 | |
dc.description.abstract | BACKGROUND: Recent studies have found low-normal potassium (K) to be associated with increased diabetes risk. We sought to verify these associations in a multi-ethnic US cohort; and to determine if these associations extend to US Hispanics and Asian-Americans. METHODS: We analyzed data from Multi-Ethnic Study of Atherosclerosis (MESA) participants who were free-of-diabetes at baseline. We examined cross-sectional associations between measures of K-serum, dietary, and urine-with fasting glucose and HOMA-IR. We examined longitudinal associations between K and diabetes risk over 8 years. FINDINGS: In multivariable models, compared to those with higher serum K (≥4.5mmol/L), those with lower serum K (<4.0mmol/L) had significantly higher fasting glucose [1.3 mg/dL (95%CI 0.2, 2.4), P-value = 0.03]. Incident diabetes developed in 1281 of 5415 at-risk participants. In minimally-adjusted models, we found inverse associations between serum and dietary K and diabetes risk. Compared to those with higher serum K, those with lower serum K had an HR (95% CI) of incident diabetes of 1.23 (1.04, 1.47), P-value = 0.02. However, these associations were attenuated in fully-adjusted models. We found no significant interaction between potassium and ethnicity. CONCLUSIONS: In this multi-ethnic cohort, we found a significant inverse association between serum K and fasting glucose but no significant association with longer-term diabetes risk. This inverse association between potassium and glucose must be studied further to understand the physiology and its potential impact on chronic health. | |
dc.identifier | ||
dc.identifier | PONE-D-16-09978 | |
dc.identifier.eissn | 1932-6203 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Public Library of Science (PLoS) | |
dc.relation.ispartof | PLoS One | |
dc.relation.isversionof | 10.1371/journal.pone.0157252 | |
dc.title | Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA). | |
dc.type | Journal article | |
duke.contributor.orcid | Svetkey, Laura P|0000-0002-3675-1282 | |
duke.contributor.orcid | Edelman, David|0000-0001-7112-6151 | |
pubs.author-url | ||
pubs.begin-page | e0157252 | |
pubs.issue | 6 | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Clinical Research Institute | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, General Internal Medicine | |
pubs.organisational-group | Medicine, Nephrology | |
pubs.organisational-group | School of Medicine | |
pubs.publication-status | Published online | |
pubs.volume | 11 |
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