Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA).

dc.contributor.author

Chatterjee, Ranee

dc.contributor.author

Zelnick, Leila

dc.contributor.author

Mukamal, Kenneth J

dc.contributor.author

Nettleton, Jennifer A

dc.contributor.author

Kestenbaum, Bryan R

dc.contributor.author

Siscovick, David S

dc.contributor.author

Ix, Joachim H

dc.contributor.author

Tracy, Russell

dc.contributor.author

Hoofnagle, Andrew N

dc.contributor.author

Svetkey, Laura P

dc.contributor.author

Edelman, David

dc.contributor.author

de Boer, Ian H

dc.contributor.editor

Schnabel, Renate B

dc.coverage.spatial

United States

dc.date.accessioned

2016-08-01T17:10:26Z

dc.date.issued

2016

dc.description.abstract

BACKGROUND: Recent studies have found low-normal potassium (K) to be associated with increased diabetes risk. We sought to verify these associations in a multi-ethnic US cohort; and to determine if these associations extend to US Hispanics and Asian-Americans. METHODS: We analyzed data from Multi-Ethnic Study of Atherosclerosis (MESA) participants who were free-of-diabetes at baseline. We examined cross-sectional associations between measures of K-serum, dietary, and urine-with fasting glucose and HOMA-IR. We examined longitudinal associations between K and diabetes risk over 8 years. FINDINGS: In multivariable models, compared to those with higher serum K (≥4.5mmol/L), those with lower serum K (<4.0mmol/L) had significantly higher fasting glucose [1.3 mg/dL (95%CI 0.2, 2.4), P-value = 0.03]. Incident diabetes developed in 1281 of 5415 at-risk participants. In minimally-adjusted models, we found inverse associations between serum and dietary K and diabetes risk. Compared to those with higher serum K, those with lower serum K had an HR (95% CI) of incident diabetes of 1.23 (1.04, 1.47), P-value = 0.02. However, these associations were attenuated in fully-adjusted models. We found no significant interaction between potassium and ethnicity. CONCLUSIONS: In this multi-ethnic cohort, we found a significant inverse association between serum K and fasting glucose but no significant association with longer-term diabetes risk. This inverse association between potassium and glucose must be studied further to understand the physiology and its potential impact on chronic health.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/27280455

dc.identifier

PONE-D-16-09978

dc.identifier.eissn

1932-6203

dc.identifier.uri

https://hdl.handle.net/10161/12563

dc.language

eng

dc.publisher

Public Library of Science (PLoS)

dc.relation.ispartof

PLoS One

dc.relation.isversionof

10.1371/journal.pone.0157252

dc.title

Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA).

dc.type

Journal article

duke.contributor.orcid

Svetkey, Laura P|0000-0002-3675-1282

duke.contributor.orcid

Edelman, David|0000-0001-7112-6151

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/27280455

pubs.begin-page

e0157252

pubs.issue

6

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Duke

pubs.organisational-group

Duke Clinical Research Institute

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Medicine

pubs.organisational-group

Medicine, General Internal Medicine

pubs.organisational-group

Medicine, Nephrology

pubs.organisational-group

School of Medicine

pubs.publication-status

Published online

pubs.volume

11

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA).pdf
Size:
195.81 KB
Format:
Adobe Portable Document Format