Single neurons may encode simultaneous stimuli by switching between activity patterns.

dc.contributor.author

Caruso, Valeria C

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Mohl, Jeff T

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Glynn, Christopher

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Lee, Jungah

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Willett, Shawn M

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Zaman, Azeem

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Ebihara, Akinori F

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Estrada, Rolando

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Freiwald, Winrich A

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Tokdar, Surya T

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Groh, Jennifer M

dc.date.accessioned

2019-01-07T19:12:25Z

dc.date.available

2019-01-07T19:12:25Z

dc.date.issued

2018-07-13

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2019-01-07T19:12:23Z

dc.description.abstract

How the brain preserves information about multiple simultaneous items is poorly understood. We report that single neurons can represent multiple stimuli by interleaving signals across time. We record single units in an auditory region, the inferior colliculus, while monkeys localize 1 or 2 simultaneous sounds. During dual-sound trials, we find that some neurons fluctuate between firing rates observed for each single sound, either on a whole-trial or on a sub-trial timescale. These fluctuations are correlated in pairs of neurons, can be predicted by the state of local field potentials prior to sound onset, and, in one monkey, can predict which sound will be reported first. We find corroborating evidence of fluctuating activity patterns in a separate dataset involving responses of inferotemporal cortex neurons to multiple visual stimuli. Alternation between activity patterns corresponding to each of multiple items may therefore be a general strategy to enhance the brain processing capacity, potentially linking such disparate phenomena as variable neural firing, neural oscillations, and limits in attentional/memory capacity.

dc.identifier

10.1038/s41467-018-05121-8

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2041-1723

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2041-1723

dc.identifier.uri

https://hdl.handle.net/10161/17888

dc.language

eng

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Springer Science and Business Media LLC

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Nature communications

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10.1038/s41467-018-05121-8

dc.subject

Auditory Cortex

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Neurons

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Animals

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Macaca mulatta

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Acoustic Stimulation

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Stereotaxic Techniques

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Electrodes, Implanted

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Auditory Perception

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Attention

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Action Potentials

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Sound

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Female

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Inferior Colliculi

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Single-Cell Analysis

dc.title

Single neurons may encode simultaneous stimuli by switching between activity patterns.

dc.type

Journal article

duke.contributor.orcid

Tokdar, Surya T|0000-0001-5162-1155

duke.contributor.orcid

Groh, Jennifer M|0000-0002-6435-3935

pubs.begin-page

2715

pubs.issue

1

pubs.organisational-group

Trinity College of Arts & Sciences

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Duke

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Psychology and Neuroscience

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Neurobiology

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Basic Science Departments

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School of Medicine

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Duke Institute for Brain Sciences

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Center for Cognitive Neuroscience

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Statistical Science

pubs.publication-status

Published

pubs.volume

9

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