Use of Letermovir for Salvage Therapy for Resistant Cytomegalovirus in a Pediatric Hematopoietic Stem Cell Transplant Recipient.
| dc.contributor.author | Kilgore, Jacob T | |
| dc.contributor.author | Becken, Bradford | |
| dc.contributor.author | Varga, Matthew G | |
| dc.contributor.author | Parikh, Suhag | |
| dc.contributor.author | Prasad, Vinod | |
| dc.contributor.author | Lugo, Debra | |
| dc.contributor.author | Chang, Yeh-Chung | |
| dc.date.accessioned | 2020-05-21T11:42:42Z | |
| dc.date.available | 2020-05-21T11:42:42Z | |
| dc.date.issued | 2019-07-31 | |
| dc.date.updated | 2020-05-21T11:42:41Z | |
| dc.description.abstract | We present here the first published use of letermovir for the treatment of resistant cytomegalovirus (CMV) in a pediatric patient. A 14-year-old girl underwent a double unrelated umbilical cord blood transplantation to treat her sickle cell disease (hemoglobin SS) and developed ganciclovir-resistant CMV DNAemia with end-organ involvement that was treated successfully with a combination of foscarnet and letermovir. After she was transitioned to letermovir monotherapy for secondary prophylaxis, she developed recurrent DNAemia with laboratory-confirmed ganciclovir, foscarnet, and letermovir resistance. | |
| dc.identifier | 5541615 | |
| dc.identifier.issn | 2048-7193 | |
| dc.identifier.issn | 2048-7207 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | Journal of the Pediatric Infectious Diseases Society | |
| dc.relation.isversionof | 10.1093/jpids/piz050 | |
| dc.subject | antiviral resistance | |
| dc.subject | cytomegalovirus (CMV) | |
| dc.subject | hematopoietic stem cell transplant | |
| dc.subject | letermovir | |
| dc.title | Use of Letermovir for Salvage Therapy for Resistant Cytomegalovirus in a Pediatric Hematopoietic Stem Cell Transplant Recipient. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Chang, Yeh-Chung|0000-0003-3073-4980 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Pediatrics, Infectious Diseases | |
| pubs.organisational-group | Medicine, Infectious Diseases | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Pediatrics | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.publication-status | Published |
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