Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.

dc.contributor.author

Foster, Chris

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Addis, Donna

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Ford, Jaclyn

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Kaufer, Daniel

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Browndyke, Jeffrey

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Welsh-Bohmer, Kathleen

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Giovanello, Kelly

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Netherlands

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2017-01-01T22:33:01Z

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2016

dc.description.abstract

Relational memory declines are well documented as an early marker for amnestic mild cognitive impairment (aMCI). Episodic memory formation relies on relational processing supported by two mnemonic mechanisms, generation and binding. Neuroimaging studies using functional magnetic resonance imaging (fMRI) have primarily focused on binding deficits which are thought to be mediated by medial temporal lobe dysfunction. In this study, prefrontal contributions to relational encoding were also investigated using fMRI by parametrically manipulating generation demands during the encoding of word triads. Participants diagnosed with aMCI and healthy control subjects encoded word triads consisting of a category word with either, zero, one, or two semantically related exemplars. As the need to generate increased (i.e., two- to one- to zero-link triads), both groups recruited a core set of regions associated with the encoding of word triads including the parahippocampal gyrus, superior temporal gyrus, and superior parietal lobule. Participants diagnosed with aMCI also parametrically recruited several frontal regions including the inferior frontal gyrus and middle frontal gyrus as the need to generate increased, whereas the control participants did not show this modulation. While there is some functional overlap in regions recruited by generation demands between the groups, the recruitment of frontal regions in the aMCI participants coincides with worse memory performance, likely representing a form of neural inefficiency associated with Alzheimer's disease.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/26937384

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S2213-1582(16)30007-9

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2213-1582

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https://hdl.handle.net/10161/13328

dc.language

eng

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MIT PRESS

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Neuroimage Clin

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10.1016/j.nicl.2016.01.008

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Aging

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Functional MRI

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Mild cognitive impairment

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Relational memory

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Aged

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Aged, 80 and over

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Alzheimer Disease

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Amnesia

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Cognitive Dysfunction

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Female

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Humans

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Image Processing, Computer-Assisted

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Magnetic Resonance Imaging

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Male

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Memory, Episodic

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Nerve Net

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Neuropsychological Tests

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Prefrontal Cortex

dc.title

Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.

dc.type

Journal article

duke.contributor.orcid

Browndyke, Jeffrey|0000-0002-8573-7073

duke.contributor.orcid

Welsh-Bohmer, Kathleen|0000-0003-1824-0179

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/26937384

pubs.begin-page

158

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166

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Clinical Science Departments

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Duke

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Duke Institute for Brain Sciences

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Duke-UNC Center for Brain Imaging and Analysis

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Institutes and Centers

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Institutes and Provost's Academic Units

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Neurology

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Neurology, Behavioral Neurology

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Psychiatry & Behavioral Sciences

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Psychiatry & Behavioral Sciences, Geriatric Behavioral Health

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Psychology and Neuroscience

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School of Medicine

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Trinity College of Arts & Sciences

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University Institutes and Centers

pubs.publication-status

Published online

pubs.volume

11

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