Histoplasmosis among hospitalized febrile patients in northern Tanzania.

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2012-08

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Abstract

Histoplasmosis may be common in East Africa but the diagnosis is rarely confirmed. We report 9 (0.9%) cases of probable histoplasmosis retrospectively identified among 970 febrile inpatients studied in northern Tanzania. Median (range) age was 31 (6, 44) years, 6 (67%) were female, 6 (67%) HIV-infected; 7 (78%) were clinically diagnosed with tuberculosis or bacterial pneumonia. Histoplasmosis is an important cause of febrile illness in Tanzania but is rarely considered in the differential diagnosis. Increased clinician awareness and availability of reliable diagnostic tests may improve patient outcomes.

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Adolescent, Adult, Child, Diagnosis, Differential, Female, Fever, HIV Seropositivity, Histoplasma, Histoplasmosis, Hospitalization, Humans, Male, Retrospective Studies, Tanzania, Tuberculosis, Young Adult

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https://hdl.handle.net/10161/13783

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10.1016/j.trstmh.2012.05.009

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Lofgren, Sarah M, Emily J Kirsch, Venance P Maro, Anne B Morrissey, Levina J Msuya, Grace D Kinabo, Wilbrod Saganda, Helmut C Diefenthal, et al. (2012). Histoplasmosis among hospitalized febrile patients in northern Tanzania. Trans R Soc Trop Med Hyg, 106(8). pp. 504–507. 10.1016/j.trstmh.2012.05.009 Retrieved from https://hdl.handle.net/10161/13783.

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Crump

John Andrew Crump

Adjunct Professor in the Department of Medicine

I am based in northern Tanzania where I am Site Leader for Duke University’s collaborative research program based at Kilimanjaro Christian Medical Centre and Director of Tanzania Operations for the Duke Global Health Institute. I oversee the design and implementation of research studies on infectious diseases, particularly febrile illness, invasive bacterial disease, HIV-associated opportunistic infections, clinical trials of antiretroviral therapy and prevention of mother-to-child transmission of HIV, and infectious diseases diagnostics. In addition, I am a medical epidemiologist with the US Centers for Disease Control and Prevention (CDC). My CDC work focuses on enteric infection epidemiology and prevention in developing countries, particularly invasive salmonelloses.

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