A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible.

dc.contributor.author

Soo, Joanne

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Kokosis, George

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Ogilvie, Michael

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Sara Jiang, Xiaoyin

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Powers, David B

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Rocke, Daniel J

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Erdmann, Detlev

dc.date.accessioned

2022-09-01T22:07:04Z

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2022-09-01T22:07:04Z

dc.date.issued

2016-12-23

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2022-09-01T22:06:56Z

dc.description.abstract

Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy. She then developed a recurrence of the mandibular alveolar ridge. The patient was successfully treated with a composite resection including a segmental mandibulectomy, buccal mucosa resection, partial glossectomy, and ipsilateral neck dissection. This was reconstructed with a free fibula osteo-septo-cutaneous flap. Mandibular OSCC is a rare complication of OLP with few reports on effective reconstructive interventions. The case represents the youngest reported patient with mandibular OSCC arising in the context of OLP and highlights the utility of the free vascularized fibula graft in the treatment of these patients.

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2169-7574

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2169-7574

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https://hdl.handle.net/10161/25659

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eng

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Ovid Technologies (Wolters Kluwer Health)

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Plastic and reconstructive surgery. Global open

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10.1097/gox.0000000000001070

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A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible.

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Journal article

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Powers, David B|0000-0003-2423-8980

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e1070

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12

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Duke

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School of Medicine

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Clinical Science Departments

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Institutes and Centers

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Pathology

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Surgery

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Surgery, Plastic, Maxillofacial, and Oral Surgery

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Duke Cancer Institute

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Head and Neck Surgery & Communication Sciences

pubs.publication-status

Published

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4

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