Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.

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2015-12

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Abstract

Limited data are available regarding the molecular epidemiology of Mycobacterium tuberculosis (Mtb) strains circulating in Guatemala. Beijing-lineage Mtb strains have gained prevalence worldwide and are associated with increased virulence and drug resistance, but there have been only a few cases reported in Central America. Here we report the first whole genome sequencing of Central American Beijing-lineage strains of Mtb. We find that multiple Beijing-lineage strains, derived from independent founding events, are currently circulating in Guatemala, but overall still represent a relatively small proportion of disease burden. Finally, we identify a specific Beijing-lineage outbreak centered on a poor neighborhood in Guatemala City.

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Beijing strains, Central America, Guatemala, Molecular epidemiology, Tuberculosis, Whole genome sequencing, China, DNA, Bacterial, Databases, Genetic, Disease Outbreaks, Genome, Bacterial, Genotype, Guatemala, Humans, Molecular Epidemiology, Mycobacterium tuberculosis, Phenotype, Phylogeny, Polymorphism, Single Nucleotide, Poverty, Predictive Value of Tests, Sequence Analysis, DNA, Tuberculosis, Urban Health

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https://hdl.handle.net/10161/11176

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10.1016/j.tube.2015.09.001

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Saelens, Joseph W, Dalia Lau-Bonilla, Anneliese Moller, Narda Medina, Brenda Guzmán, Maylena Calderón, Raúl Herrera, Dana M Sisk, et al. (2015). Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak. Tuberculosis (Edinb), 95(6). pp. 810–816. 10.1016/j.tube.2015.09.001 Retrieved from https://hdl.handle.net/10161/11176.

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Stout

Jason Eric Stout

Professor of Medicine

My research focuses on the epidemiology, natural history, and treatment of tuberculosis and nontuberculous mycobacterial infections. I am also interested in the impact of HIV infection on mycobacterial infection and disease, and in examining health disparities as they relate to infectious diseases, particularly in immigrant populations.

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