Leukocyte telomere length is associated with disability in older u.s. Population.

Risques, Rosa Ana

Arbeev, Konstantin G

Yashin, Anatoli I

Ukraintseva, Svetlana V

Martin, George M

Rabinovitch, Peter S

Oshima, Junko

United States

2017-06-07T19:31:49Z

2017-06-07T19:31:49Z

2010-07

OBJECTIVES: To determine whether mean leukocyte telomere length (LTL) serves as a biomarker of disability assessed according to activities of daily living (ADLs) and what factors may modify this relationship. DESIGN: Retrospective cross-sectional study. SETTING: A subset of the National Long Term Care Survey (NTLCS), a Medicare-based U.S. population longitudinal study focused on trends of overall health and functional status in older adults. PARTICIPANTS: Six hundred and twenty-four individuals from the 1999 wave of the NTLCS cohort. MEASUREMENTS: Relative LTL determined according to quantitative polymerase chain reaction. LTL has previously been shown to correlate with common age-related disorders and mortality, as well as with socioeconomic status. RESULTS: A sex difference in LTL was observed but not age-dependent shortening or association with socioeconomic status. LTL was associated with disability and functional status assessed according to ADLs. The association between ADLs and LTL was stronger in subjects without diabetes mellitus, whereas associations were not seen when only subjects with diabetes mellitus were analyzed. Associations between LTL and cardiovascular disease (CVD) and cancer were also present in the group without diabetes mellitus but not in the group with diabetes mellitus. CONCLUSION: These findings support the concept that LTL is a biomarker of overall well-being that is predictive of disability of older individuals in the U.S. population. Diabetes mellitus plays an important role as a modifier of the association between LTL and disability, CVD, and cancer. These associations have clinical implications because of the potential predictive value of LTL and deserve further investigation.

https://www.ncbi.nlm.nih.gov/pubmed/20579170

JGS2948

1532-5415

https://hdl.handle.net/10161/14880

eng

Wiley

J Am Geriatr Soc

10.1111/j.1532-5415.2010.02948.x

Activities of Daily Living

Age Factors

Aged

Aged, 80 and over

Biomarkers

Cross-Sectional Studies

Disability Evaluation

Female

Geriatric Assessment

Humans

Leukocytes

Male

Predictive Value of Tests

Retrospective Studies

Sex Factors

Socioeconomic Factors

Telomere

Leukocyte telomere length is associated with disability in older u.s. Population.

Journal article

Arbeev, Konstantin G|0000-0002-4195-7832

https://www.ncbi.nlm.nih.gov/pubmed/20579170

1289

1298

7

Center for Population Health & Aging

Duke

Duke Cancer Institute

Duke Population Research Center

Duke Population Research Institute

Institutes and Centers

Institutes and Provost's Academic Units

Sanford School of Public Policy

School of Medicine

Social Science Research Institute

Staff

University Institutes and Centers

Published

58