Diffuse interface model for cell interaction and aggregation with Lennard-Jones type potential

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2023-10-01

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Abstract

This study introduces a phase-field model designed to simulate the interaction and aggregation of multicellular systems under flow conditions within a bounded spatial domain. The model incorporates a multi-dimensional Lennard-Jones potential to account for short-range repulsion and adhesive bonding between cells. To solve the governing equations while preserving energy law, a second-order accurate C0 finite element method is employed. The validity of the model is established through numerical tests, and experimental data from cell stretch tests is utilized for model calibration and validation. Additionally, the study investigates the impact of varying adhesion properties in red blood cells. Overall, this work presents a thermodynamically consistent and computationally efficient framework for simulating cell–cell and cell–wall interactions under flow conditions.

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10.1016/j.cma.2023.116257

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Shen, L, P Lin, Z Xu and S Xu (2023). Diffuse interface model for cell interaction and aggregation with Lennard-Jones type potential. Computer Methods in Applied Mechanics and Engineering, 415. pp. 116257–116257. 10.1016/j.cma.2023.116257 Retrieved from https://hdl.handle.net/10161/28785.

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Xu

Shixin Xu

Assistant Professor of Mathematics at Duke Kunshan University

Shixin Xu is an Assistant Professor of Mathematics.   His research interests are machine learning and data-driven models for diseases,  multiscale modeling of complex fluids, Neurovascular coupling, homogenization theory, and numerical analysis.  The current projects he is working on are

  • image data-based for the prediction of hemorrhagic transformation in acute ischemic stroke,
  • electrodynamics modeling of saltatory conduction along a myelinated axon
  • electrochemical modeling
  • fluid-structure interaction with mass transportation and reaction

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