Ghrelin Regulation of Glucose Metabolism.

Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are implicated in the regulation of glucose metabolism through direct actions in the pancreatic islet as well as peripheral insulin-sensitive tissues and brain. While many studies have explored the role of ghrelin in glucose tolerance and insulin secretion, a complete mechanistic understanding has yet to be elucidated. This review highlights the local expression and function of ghrelin and GHSR1a in pancreatic islets and how this axis may modulate insulin secretion from pancreatic β-cells. Additionally, we discuss the effect of ghrelin on in vivo glucose metabolism in rodents and humans and the metabolic circumstances under which ghrelin action may predominate. This article is protected by copyright. All rights reserved.