What is in a prayer sign?
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<jats:p>We juxtapose two patients—one with type 2 diabetes and one with systemic sclerosis (SSc)—who both exhibited severe hand joint restriction. Despite similar clinical findings, MRI revealed inflammatory tenosynovitis in SSc versus non-inflammatory fibrotic changes in diabetes. This comparison of clinical similarities and imaging differences highlights how a shared phenotype—the “prayer sign”—can arise from divergent mechanisms, and also suggest its potential use as a visible biomarker of systemic fibrosis with disease-specific implications.</jats:p>
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Phatak, Sanat, Pranav Mahadevkar, Jennifer L Ingram and Chittaranjan Yajnik (n.d.). What is in a prayer sign?. ScienceBank. 10.61340/wiaps01 Retrieved from https://hdl.handle.net/10161/34924.
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Jennifer Leigh Ingram
Dr. Ingram's research interests focus on the study of airway remodeling in human asthma. Proliferation, migration, and invasion of airway fibroblasts are key features of airway remodeling that contribute to diminished lung function over time. Dr. Ingram uses molecular biology approaches to define the effects of interleukin-13 (IL-13), a cytokine abundantly produced in the asthmatic airway, in the human airway fibroblast. She has identified important regulatory functions of several proteins prevalent in asthma that control fibroblast growth and pro-fibrotic growth factor production in response to IL-13. By understanding these pathways and their role in human asthma and the chronic effects of airway remodeling, novel treatment strategies may be developed.
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