An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.

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2016-01-01

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Abstract

We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.

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10.1177/0962280216680524

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Matsouaka, Roland A, Aneesh B Singhal and Rebecca A Betensky (2016). An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome. Stat Methods Med Res. p. 962280216680524. 10.1177/0962280216680524 Retrieved from https://hdl.handle.net/10161/13352.

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Matsouaka

Roland Albert Matsouaka

Associate Professor of Biostatistics & Bioinformatics

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