Average Weighted Accuracy: Pragmatic Analysis for a Rapid Diagnostics in Categorizing Acute Lung Infections (RADICAL) Study.

dc.contributor.author

Liu, Ying

dc.contributor.author

Tsalik, Ephraim L

dc.contributor.author

Jiang, Yunyun

dc.contributor.author

Ko, Emily R

dc.contributor.author

Woods, Christopher W

dc.contributor.author

Henao, Ricardo

dc.contributor.author

Evans, Scott R

dc.date.accessioned

2020-11-01T14:36:26Z

dc.date.available

2020-11-01T14:36:26Z

dc.date.issued

2020-06

dc.date.updated

2020-11-01T14:36:25Z

dc.description.abstract

Patient management relies on diagnostic information to identify appropriate treatment. Standard evaluations of diagnostic tests consist of estimating sensitivity, specificity, positive/negative predictive values, likelihood ratios, and accuracy. Although useful, these metrics do not convey the tests' clinical value, which is critical to informing decision-making. Full appreciation of the clinical impact of a diagnostic test requires analyses that integrate sensitivity and specificity, account for the disease prevalence within the population of test application, and account for the relative importance of specificity vs sensitivity by considering the clinical implications of false-positive and false-negative results. We developed average weighted accuracy (AWA), representing a pragmatic metric of diagnostic yield or global utility of a diagnostic test. AWA can be used to compare test alternatives, even across different studies. We apply the AWA methodology to evaluate a new diagnostic test developed in the Rapid Diagnostics in Categorizing Acute Lung Infections (RADICAL) study.

dc.identifier

5510415

dc.identifier.issn

1058-4838

dc.identifier.issn

1537-6591

dc.identifier.uri

https://hdl.handle.net/10161/21655

dc.language

eng

dc.publisher

Oxford University Press (OUP)

dc.relation.ispartof

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

dc.relation.isversionof

10.1093/cid/ciz437

dc.subject

average weighted accuracy (AWA)

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diagnostic test

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diagnostic yield

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prevalence

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relative importance

dc.title

Average Weighted Accuracy: Pragmatic Analysis for a Rapid Diagnostics in Categorizing Acute Lung Infections (RADICAL) Study.

dc.type

Journal article

duke.contributor.orcid

Tsalik, Ephraim L|0000-0002-6417-2042

duke.contributor.orcid

Woods, Christopher W|0000-0001-7240-2453

duke.contributor.orcid

Henao, Ricardo|0000-0003-4980-845X

pubs.begin-page

2736

pubs.end-page

2742

pubs.issue

12

pubs.organisational-group

School of Medicine

pubs.organisational-group

Medicine, General Internal Medicine

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Duke

pubs.organisational-group

Medicine

pubs.organisational-group

Clinical Science Departments

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Duke Global Health Institute

pubs.organisational-group

Pathology

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Medicine, Infectious Diseases

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Electrical and Computer Engineering

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Duke Clinical Research Institute

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Biostatistics & Bioinformatics

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Pratt School of Engineering

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Institutes and Centers

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Basic Science Departments

pubs.organisational-group

Molecular Genetics and Microbiology

pubs.publication-status

Published

pubs.volume

70

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