Invasive hydatidiform mole of the lung with an implantation site intermediate trophoblast: Report of a case supporting the pathways of trophoblast differentiation.

My research program, largely histopathological, concerns definitions of criteria, biological properties, differential diagnosis, and survival associated with pathological lesions in the female genital tract. With the gynecologic oncologists at Duke, we have reviewed the Institution's long term experience of endometrial cancer and with the International Collaborative Group on Endometrium, we have developed a new classification system for endometrial hyperplasia that better differentiates precancerous from benign lesions. In a nationwide NIH study in which I head the pathology review, long term complications in both sons and daughters from prenatal exposure to DES are being assessed. A major initiative is a study of vulvar dermatoses and unusual vulvar neoplasms. A final clinical pathologic correlation study, ongoing for over 40 years, has been the long term follow-up of a very rare tumor (malignant struma ovarii). Long term study has been required to identify those features that will ultimately prove to be of biologic significance for defining cases which will likely recur.