Use of Letermovir as Salvage Therapy for Drug-resistant CMV Retinitis: A Case Series
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Citation Stats
Abstract
<jats:p>Treatment options for drug-resistant CMV are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but efficacy in other settings is unknown. We recently used letermovir for salvage treatment in four solid organ transplant recipients with ganciclovir-resistant CMV retinitis. All patients improved clinically without known adverse drug events. However, three patients failed to maintain virologic suppression, including two patients who developed genotypically-confirmed resistance to letermovir while on therapy.</jats:p>
Type
Department
Description
Provenance
Subjects
Citation
Permalink
Published Version (Please cite this version)
Publication Info
Turner, Nicholas, Andrew Strand, Dilraj S Grewal, Gary Cox, Sana Arif, Arthur W Baker, Eileen K Maziarz, Jennifer H Saullo, et al. (n.d.). Use of Letermovir as Salvage Therapy for Drug-resistant CMV Retinitis: A Case Series. Antimicrobial Agents and Chemotherapy. 10.1128/aac.02337-18 Retrieved from https://hdl.handle.net/10161/17912.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
Scholars@Duke
Nicholas Turner
Dilraj Singh Grewal
Vitreoretinal and Uveitis Specialist
Dilraj Grewal, MD is a tenured Associate Professor of Ophthalmology at the Duke Eye Center. He specializes in the medical and surgical management of patients with complex Vitreoretinal pathology and Uveitis. He joined the Duke Eye Center following completion of his Vitreoretinal Surgery fellowship at Duke and Uveitis fellowship training at Moorfields Eye Hospital in London. Dr. Grewal is excited about treating patients with new diagnostic and therapeutic modalities available as well as investigating several others in the pipeline to better help patients with these potentially blinding diseases.
He has been the recipient of numerous prestigious awards including the Ronald G. Michels Foundation Fellowship Award, the Heed Ophthalmic Foundation Fellowship Award, Senior Achievement Award from the American Academy of Ophthalmology and Rhett Buckler and Presidential Awards from American Society of Retina Specialists. He is an elected member of Retina Society, Clubs Jules Gonin and serves on the executive committee of the Macula Society.
Dr. Grewal has authored over 190 publications in peer-reviewed medical journals and over 250 presentations at national and international meetings. His research interests span assessment of retinal changes in neurodegenerative diseases, clinical research activities in advanced ocular imaging, surgical techniques and clinical trials for both Retina and Uveitis. Dr Grewal also serves as the Associate Director of the Duke Reading Center, a comprehensive image reading center that specializes in systematic analysis of ophthalmic images in multi-center clinical trials.
Gary Matthew Cox
Sana Arif
Arthur Wakefield Baker
Eileen Maziarz
Jennifer H. Saullo
Cameron Robert Wolfe
HIV infection, Transplant-related infectious diseases, general infectious diseases, Biological and Emergency Preparedness for hospital systems, influenza and respiratory viral pathogens
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.