Mapping SARS-CoV-2 antigenic relationships and serological responses.

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Wilks, Samuel H

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Mühlemann, Barbara

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Shen, Xiaoying

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Türeli, Sina

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LeGresley, Eric B

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Netzl, Antonia

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Caniza, Miguela A

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Chacaltana-Huarcaya, Jesus N

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Corman, Victor M

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Daniell, Xiaoju

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Datto, Michael B

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Dawood, Fatimah S

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Denny, Thomas N

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Drosten, Christian

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Fouchier, Ron AM

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Garcia, Patricia J

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Halfmann, Peter J

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Jassem, Agatha

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Jeworowski, Lara M

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Jones, Terry C

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Kawaoka, Yoshihiro

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Krammer, Florian

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McDanal, Charlene

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Pajon, Rolando

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Simon, Viviana

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Stockwell, Melissa S

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Tang, Haili

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van Bakel, Harm

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Veguilla, Vic

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Webby, Richard

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Montefiori, David C

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Smith, Derek J

dc.date.accessioned

2022-08-08T16:31:05Z

dc.date.available

2022-08-08T16:31:05Z

dc.date.issued

2022-07-13

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2022-08-08T16:31:03Z

dc.description.abstract

During the SARS-CoV-2 pandemic, multiple variants with differing amounts of escape from pre-existing immunity have emerged, causing concerns about continued protection. Here, we use antigenic cartography to quantify and visualize the antigenic relationships among 16 SARS-CoV-2 variants titrated against serum samples taken post-vaccination and post-infection with seven different variants. We find major antigenic differences caused by substitutions at spike positions 417, 452, 484, and possibly 501. B.1.1.529 (Omicron BA.1) showed the highest escape from all sera tested. Visualization of serological responses as antibody landscapes shows how reactivity clusters in different regions of antigenic space. We find changes in immunodominance of different spike regions depending on the variant an individual was exposed to, with implications for variant risk assessment and vaccine strain selection. One sentence summary: Antigenic Cartography of SARS-CoV-2 variants reveals amino acid substitutions governing immune escape and immunodominance patterns.

dc.identifier.uri

https://hdl.handle.net/10161/25583

dc.language

eng

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bioRxiv

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10.1101/2022.01.28.477987

dc.title

Mapping SARS-CoV-2 antigenic relationships and serological responses.

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Journal article

duke.contributor.orcid

Shen, Xiaoying|0000-0001-8076-1931|0000-0002-8387-3952

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Duke

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School of Medicine

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Clinical Science Departments

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Institutes and Centers

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Medicine

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Medicine, Duke Human Vaccine Institute

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Duke Human Vaccine Institute

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Institutes and Provost's Academic Units

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University Institutes and Centers

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Duke Global Health Institute

pubs.publication-status

Published online

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