The <i>tilt</i> ( <i>tt</i> ) mutation of <i>Drosophila melanogaster</i> maps to the cis-regulatory region of the Iroquois Complex (Iro-C) located in the <i>sosondowah</i> ( <i>sowah)</i> gene.
Date
2025-01
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Citation Stats
Attention Stats
Abstract
The tilt ( tt ) mutation first described by Morgan and Bridges in 1915 has adult visible phenotypes in wing posture and vein formation. We have mapped tt to a genomic region within the sosondowah ( sowah ) gene that houses the cis-regulatory elements that control expression of the Iroquois Complex genes araucan ( ara ) and caup olican ( caup ) in the wing hinge and wing veins. Sequence analysis of the tt1 allele has identified a gtwin retrotransposon containing su(Hw) insulator binding sites within this region of sowah . We find that mutations in su(Hw) suppress the tilt phenotype, providing a potential mechanism for the insertion to affect the function of the Iroquois Complex.
Type
Department
Description
Provenance
Subjects
Citation
Permalink
Published Version (Please cite this version)
Publication Info
Gruber, Samuel, Arno Houtman, Hailey Reisert, Mina Amini, Caroline Fiore, Paula Gonzalez, Veronica Han, Aeva Jazic, et al. (2025). The <i>tilt</i> ( <i>tt</i> ) mutation of <i>Drosophila melanogaster</i> maps to the cis-regulatory region of the Iroquois Complex (Iro-C) located in the <i>sosondowah</i> ( <i>sowah)</i> gene. microPublication biology, 2025. 10.17912/micropub.biology.001704 Retrieved from https://hdl.handle.net/10161/33755.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
Scholars@Duke
Eric P. Spana
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.