Injectable, Solvent Free Strontium Carbonate Poly(Allyl Glycidyl Ether Succinate) Composite Networks for Vertebral Augmentation.
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2025-06
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Vertebral body compression fractures are a major cause of chronic back pain, particularly in older adults. Augmentation is currently performed by injecting a poly(methyl methacrylate) (PMMA) slurry of polymer, monomer, and initiator mixed with barium sulfate (BaSO4) into the vertebrae, which then polymerizes in vivo. Herein, a solvent-free polymer system using poly(allyl glycidyl ether succinate) (PAGES) is developed for vertebral augmentation. PAGES crosslinks in situ through thiol-ene click chemistry with a cure time at 37 °C ranging from 17 to 53 min based on degree of polymerization and crosslinker concentration. The addition of SrCO3 increased the ultimate compressive strength (σmax) of the PAGES composite to 4.4 ± 0.4 MPa. Furthermore, SrCO3 increases osteoblast proliferation and differentiation of mesenchymal stem cells seeded onto the surface of PAGES composite. Finally, the compressive strength of fractured vertebrae is increased in an ex vivo surrogate rabbit model when filled with injected PAGES composite, demonstrating its potential as a bone augmentation material.
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Thompson, Russell E, Maddison I Segal, Stephanie Sipics, Nicola G Judge, Alexia Bensoussan, Bavand Keshavarz and Matthew L Becker (2025). Injectable, Solvent Free Strontium Carbonate Poly(Allyl Glycidyl Ether Succinate) Composite Networks for Vertebral Augmentation. Advanced healthcare materials. p. e2501633. 10.1002/adhm.202501633 Retrieved from https://hdl.handle.net/10161/32521.
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Scholars@Duke
Bavand Keshavarz
Research interests of Keshavarz’s group are at the intersection of fluid dynamics and soft matter mechanics. We are particularly interested in dynamics of complex fluids in complex flows. Inspired by the biofabrication process of natural hydrogels, we aim to harness hydrodynamic instabilities to fabricate responsive soft apparatuses that exhibit dynamic functionality over a wide range of deformation timescales. Our approach incorporates a number of interdisciplinary studies on properties of complex fluids with functional biomolecules, capillary phenomena of viscoelastic solutions, gelation of supramolecular networks and mechanical spectroscopy or rheology of gelling systems during linear and nonlinear deformations. These will enable us to both understand and mimic the hierarchical organization of dynamic properties that is often observed in elaborate biological soft structures.
Matthew L Becker
The Becker Laboratory for Functional Biomaterials is a multidisciplinary organic materials group working at the interface of chemistry, engineering and medicine. We are developing families of degradable polymers with highly tunable physical and biological properties that are being applied to unmet needs in flexible electronics, soft tissue repair, neural, orthopedic and vascular tissue engineering. We are also actively engaged in additive manufacturing and the development of custom inks that are enabling unique solutions to challenging design paradigms in biomaterials and drug delivery.
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