Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance.

Cauley, Marty

Hall, Brandon J

Abreu-Villaça, Yael

Junaid, Shaqif

White, Hannah

Kiany, Abtin

Slotkin, Theodore A

Levin, Edward D

2024-01-01T15:47:13Z

2024-01-01T15:47:13Z

2018-09

Tobacco exposure during development leads to neurobehavioral dysfunction in children, even when exposure is limited to secondhand smoke. We have previously shown in rats that developmental exposure to tobacco smoke extract (TSE), at levels mimicking secondhand smoke, starting preconception and extending throughout gestation, evoked subsequent locomotor hyperactivity and cognitive impairment. These effects were greater than those caused by equivalent exposures to nicotine alone, implying that other agents in tobacco smoke contributed to the adverse behavioral effects. In the present study, we examined the critical developmental windows of vulnerability for these effects, restricting TSE administration (0.2 mg/kg/day nicotine equivalent, or DMSO vehicle, delivered by subcutaneously-implanted pumps) to three distinct 10 day periods: the 10 days preceding mating, the first 10 days of gestation (early gestation), or the second 10 days of gestation (late gestation). The principal behavioral effects revealed a critical developmental window of vulnerability, as well as sex selectivity. Late gestational TSE exposure significantly increased errors in the initial training on the radial-arm maze in female offspring, whereas no effects were seen in males exposed during late gestation, or with either sex in the other exposure windows. In attentional testing with the visual signal detection test, male offspring exposed to TSE during early or late gestation showed hypervigilance during low-motivating conditions. These results demonstrate that gestational TSE exposure causes persistent behavioral effects that are dependent on the developmental window in which exposure occurs. The fact that effects were seen at TSE levels modeling secondhand smoke, emphasizes the need for decreasing involuntary tobacco smoke exposure, particularly during pregnancy.

S0161-813X(18)30287-0

0161-813X

1872-9711

https://hdl.handle.net/10161/29581

eng

Elsevier BV

Neurotoxicology

10.1016/j.neuro.2018.07.012

https://creativecommons.org/licenses/by-nc/4.0

Animals

Rats, Sprague-Dawley

Prenatal Exposure Delayed Effects

Behavior, Animal

Exploratory Behavior

Motor Activity

Choice Behavior

Tobacco Smoke Pollution

Pregnancy

Female

Male

Nicotiana

Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance.

Journal article

Levin, Edward D|0000-0002-5060-9602

81

87

Duke

Nicholas School of the Environment

School of Medicine

Trinity College of Arts & Sciences

Basic Science Departments

Clinical Science Departments

Institutes and Centers

Neurobiology

Pharmacology & Cancer Biology

Psychiatry & Behavioral Sciences

Duke Cancer Institute

Psychology & Neuroscience

Environmental Sciences and Policy

Institutes and Provost's Academic Units

University Institutes and Centers

Duke Institute for Brain Sciences

Initiatives

Duke Science & Society

Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences

Published

68