Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy.
| dc.contributor.author | Lee, Hedok | |
| dc.contributor.author | Xu, Feng | |
| dc.contributor.author | Liu, Xiaodan | |
| dc.contributor.author | Koundal, Sunil | |
| dc.contributor.author | Zhu, Xiaoyue | |
| dc.contributor.author | Davis, Judianne | |
| dc.contributor.author | Yanez, David | |
| dc.contributor.author | Schrader, Joseph | |
| dc.contributor.author | Stanisavljevic, Aleksandra | |
| dc.contributor.author | Rothman, Douglas L | |
| dc.contributor.author | Wardlaw, Joanna | |
| dc.contributor.author | Van Nostrand, William E | |
| dc.contributor.author | Benveniste, Helene | |
| dc.date.accessioned | 2024-06-11T13:47:24Z | |
| dc.date.available | 2024-06-11T13:47:24Z | |
| dc.date.issued | 2021-05 | |
| dc.description.abstract | Diffuse white matter (WM) disease is highly prevalent in elderly with cerebral small vessel disease (cSVD). In humans, cSVD such as cerebral amyloid angiopathy (CAA) often coexists with Alzheimer's disease imposing a significant impediment for characterizing their distinct effects on WM. Here we studied the burden of age-related CAA pathology on WM disease in a novel transgenic rat model of CAA type 1 (rTg-DI). A cohort of rTg-DI and wild-type rats was scanned longitudinally using MRI for characterization of morphometry, cerebral microbleeds (CMB) and WM integrity. In rTg-DI rats, a distinct pattern of WM loss was observed at 9 M and 11 M. MRI also revealed manifestation of small CMB in thalamus at 6 M, which preceded WM loss and progressively enlarged until the moribund disease stage. Histology revealed myelin loss in the corpus callosum and thalamic CMB in all rTg-DI rats, the latter of which manifested in close proximity to occluded and calcified microvessels. The quantitation of CAA load in rTg-DI rats revealed that the most extensive microvascular Aβ deposition occurred in the thalamus. For the first time using in vivo MRI, we show that CAA type 1 pathology alone is associated with a distinct pattern of WM loss. | |
| dc.identifier.issn | 0271-678X | |
| dc.identifier.issn | 1559-7016 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | SAGE Publications | |
| dc.relation.ispartof | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism | |
| dc.relation.isversionof | 10.1177/0271678x20944226 | |
| dc.rights.uri | ||
| dc.subject | Brain | |
| dc.subject | Thalamus | |
| dc.subject | Corpus Callosum | |
| dc.subject | Animals | |
| dc.subject | Rats | |
| dc.subject | Cerebral Amyloid Angiopathy | |
| dc.subject | Cerebral Hemorrhage | |
| dc.subject | Calcinosis | |
| dc.subject | Disease Models, Animal | |
| dc.subject | Magnetic Resonance Imaging | |
| dc.subject | Case-Control Studies | |
| dc.subject | Female | |
| dc.subject | Male | |
| dc.subject | Rats, Transgenic | |
| dc.subject | Microvessels | |
| dc.subject | Diffusion Tensor Imaging | |
| dc.subject | Cerebral Small Vessel Diseases | |
| dc.subject | White Matter | |
| dc.subject | Global Burden of Disease | |
| dc.title | Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Yanez, David|0000-0002-2501-5028 | |
| pubs.begin-page | 1103 | |
| pubs.end-page | 1118 | |
| pubs.issue | 5 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Biostatistics & Bioinformatics | |
| pubs.organisational-group | Biostatistics & Bioinformatics, Division of Biostatistics | |
| pubs.publication-status | Published | |
| pubs.volume | 41 |
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