Gender-specific structural abnormalities in major depressive disorder revealed by fixel-based analysis.

Thumbnail Image
View / Download971.62 KB

Date

2019-01-08

Authors

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

22
views
17
downloads

Citation Stats

Abstract

Background

Major depressive disorder (MDD) is a chronic disease with a large global impact. There are currently no clinically useful predictors of treatment outcome, and the development of biomarkers to inform clinical treatment decisions is highly desirable.

Methods

In this exploratory study we performed fixel-based analysis of diffusion MRI data from the International Study to Predict Optimized Treatment in Depression with the aim of identifying novel biomarkers at baseline that may relate to diagnosis and outcome to treatment with antidepressant medications. Analyses used MR data from individuals with MDD (n = 221) and healthy controls (n = 67).

Results

We show focal, gender-specific differences in the anterior limb of the internal capsule (males) and bilaterally in the genu of the corpus callosum (females) associated with diagnosis. Lower fibre cross-section in the tapetum, the conduit between the right and left hippocampi, were also associated with a decreased probability of remission. Analysis of conventional fractional anisotropy showed scattered abnormalities in the corona radiata, cerebral peduncles and mid-brain which were much lower in total volume compared to fixel-based analysis.

Conclusions

Fixel-based analysis appeared to identify different underlying abnormalities than conventional tensor-based metrics, with almost no overlap between significant regions. We show that MDD is associated with gender specific abnormalities in the genu of the corpus callosum (females) and in the anterior limb of the internal capsule (males), as well as gender-independent differences in the tapetum that predict remission. Diffusion MRI may play a key role in future guidance of clinical decision-making for MDD.

Type

Journal article

Department

Description

Provenance

Subjects

Corpus Callosum, Internal Capsule, Humans, Magnetic Resonance Imaging, Cohort Studies, Depressive Disorder, Major, Psychiatric Status Rating Scales, Sex Characteristics, Anisotropy, Adult, Female, Male, Diffusion Tensor Imaging, White Matter

Citation

Permalink

https://hdl.handle.net/10161/24814

Published Version (Please cite this version)

10.1016/j.nicl.2019.101668

Publication Info

Lyon, Matt, Thomas Welton, Adrina Varda, Jerome J Maller, Kathryn Broadhouse, Mayuresh S Korgaonkar, Stephen H Koslow, Leanne M Williams, et al. (2019). Gender-specific structural abnormalities in major depressive disorder revealed by fixel-based analysis. NeuroImage. Clinical, 21. p. 101668. 10.1016/j.nicl.2019.101668 Retrieved from https://hdl.handle.net/10161/24814.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.

Collections

Scholarly Articles
Full item page

Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.