A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance.
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2017
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In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.
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Howard, Brandon A, Olga G James, Jennifer M Perkins, Robert A Pagnanelli, Salvador Borges-Neto and Robert E Reiman (2017). A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance. SAGE Open Med Case Rep, 5. 10.1177/2050313X17745203 Retrieved from https://hdl.handle.net/10161/16135.
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Brandon Augustus Howard
Robert Ellis Reiman
Dr. Reiman is diplomate of the American Board of Nuclear Medicine, and is the Associate Director the Radiation Safety Division of Duke's Occupational and Environmental Safety Office. He is on the faculty the Department of Radiology and is a member of the Faculty of the Duke Medical Physics Graduate Program. He coordinates the patient care activities of the Duke Radiation Safety Division and participates in the teaching of radiology residents, nuclear medicine fellows, cardiology fellows and medical students. His current research interests include internal radionuclide dosimetry and the application of Web-based systems to problems in radiation safety and dosimetry. He has also published on imaging of bone, brain and soft-tissue tumors with nitrogen-13 labeled amino acids.
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