HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.

dc.contributor.author

Nyanhete, Tinashe E

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Frisbee, Alyse L

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Bradley, Todd

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Faison, William J

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Robins, Elizabeth

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Payne, Tamika

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Freel, Stephanie A

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Sawant, Sheetal

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Weinhold, Kent J

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Wiehe, Kevin

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Haynes, Barton F

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Ferrari, Guido

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Li, Qi-Jing

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Moody, M Anthony

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Tomaras, Georgia D

dc.date.accessioned

2020-12-01T15:11:11Z

dc.date.available

2020-12-01T15:11:11Z

dc.date.issued

2019-07-15

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2020-12-01T15:11:08Z

dc.description.abstract

A paradigm shifting study demonstrated that induction of MHC class E and II-restricted CD8+ T cells was associated with the clearance of SIV infection in rhesus macaques. Another recent study highlighted the presence of HIV-1-specific class II-restricted CD8+ T cells in HIV-1 patients who naturally control infection (virus controllers; VCs). However, questions regarding class II-restricted CD8+ T cells ontogeny, distribution across different HIV-1 disease states and their role in viral control remain unclear. In this study, we investigated the distribution and anti-viral properties of HLA-DRB10701 and DQB10501 class II-restricted CD8+ T cells in different HIV-1 patient cohorts; and whether class II-restricted CD8+ T cells represent a unique T cell subset. We show that memory class II-restricted CD8+ T cell responses were more often detectable in VCs than in chronically infected patients, but not in healthy seronegative donors. We also demonstrate that VC CD8+ T cells inhibit virus replication in both a class I- and class II-dependent manner, and that in two VC patients the class II-restricted CD8+ T cells with an anti-viral gene signature expressed both CD4+ and CD8+ T cell lineage-specific genes. These data demonstrated that anti-viral memory class II-restricted CD8+ T cells with hybrid CD4+ and CD8+ features are present during natural HIV-1 infection.

dc.identifier

10.1038/s41598-019-46462-8

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2045-2322

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2045-2322

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https://hdl.handle.net/10161/21777

dc.language

eng

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Springer Science and Business Media LLC

dc.relation.ispartof

Scientific reports

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10.1038/s41598-019-46462-8

dc.subject

CD4-Positive T-Lymphocytes

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CD8-Positive T-Lymphocytes

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Humans

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HIV-1

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HIV Infections

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HIV Seropositivity

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Histocompatibility Antigens Class II

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Viral Load

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Virus Replication

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Adult

dc.subject

Female

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Male

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HLA-DQ beta-Chains

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HLA-DRB1 Chains

dc.title

HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.

dc.type

Journal article

duke.contributor.orcid

Ferrari, Guido|0000-0001-7747-3349

duke.contributor.orcid

Li, Qi-Jing|0000-0002-0542-9784

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Moody, M Anthony|0000-0002-3890-5855

duke.contributor.orcid

Tomaras, Georgia D|0000-0001-8076-1931

pubs.begin-page

10165

pubs.issue

1

pubs.organisational-group

School of Medicine

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Duke Human Vaccine Institute

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Immunology

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Pediatrics, Infectious Diseases

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Duke

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Institutes and Centers

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Basic Science Departments

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Pediatrics

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Clinical Science Departments

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Staff

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Duke Cancer Institute

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Pathology

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Surgery, Surgical Sciences

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Surgery

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Duke Global Health Institute

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Medicine, Duke Human Vaccine Institute

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Medicine

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Molecular Genetics and Microbiology

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Duke Innovation & Entrepreneurship

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Initiatives

pubs.publication-status

Published

pubs.volume

9

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